Lewis Shi, Ph.D. Lewis Zhichang Shi, Ph.D., Associate Professor in the UAB Department of Radiation Oncology, has been awarded a Clinic and Laboratory Integration Program (CLIP) grant from the Cancer Research Institute (CRI).

CLIP grants provide up to $200,000 over a two-year period to support investigators like Shi who are studying critical topics at the intersection of laboratory and clinical research, known as translational research.

Shi’s CLIP project is titled, “Discovering and targeting tumor-intrinsic metabolic checkpoints to overcome immunotherapy resistance.”

“This CRI grant will allow me to tackle a major mechanism of resistance to immunotherapy in colorectal cancer, melanoma, and bladder cancer, a pressing unmet medical need,” Shi said.

Shi’s recent research on immunotherapy resistance in melanoma patients, “Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling,” was recently published in Nature Communications and recognized as the latest “Featured Discovery” by the UAB Heersink School of Medicine. Shi is also a scientist in the O’Neal Comprehensive Cancer Center at UAB.

Read Shi’s CLIP investigator profile here.