Assistant Professor email
VH G094
(205) 996-0826

Visit Dr. Rosa-Garrido's Research Website

Research and Teaching Interests: Epigenetics, Chromatin Structure, Heart Disease

Office Hours: By appointment

Education:

• B.S. Biology, University of Jaen (Spain)
• B.S. Biochemistry, University of Granada (Spain)
• Ph.D. Biomedicine, University of Cantabria (Spain)
• Post-Doc, University of California Los Angeles

Dr. Rosa-Garrido received his Ph.D. from the University of Cantabria (Spain) for his work studying the role of the epigenetic chromatin organizer CTCF in leukemia, lymphoma, and skin cancer. During his post-doctoral training at UCLA, Dr. Rosa-Garrido sought to apply what he learned from the cancer field to heart disease. During this stage, he demonstrated how the modulation of chromatin structure plays an essential role in the development of cardiac disease. In 2022 Dr. Rosa Garrido was recruited by the Department of Bioengineering, where he leads a research group focused on defining the direct and indirect role that chromatin structure plays in mediating cardiac pathology.

Research interest:

Dr. Rosa-Garrido investigates the functional role of chromatin reorganization in the setting of heart failure by combining his expertise in epigenomics and cardiac physiology. His group performs chromosome conformation capture (Hi-C), chromatin accessibility (ATAC-seq), bisulfite sequencing and gene expression profiling in different cardiac disease models to identify pathological structural patterns that can be used as predictive markers and targets of epigenetic therapies. To study the translational implications of his research, Dr. Rosa-Garrido’s lab also uses human heart tissue to compare chromatin remodeling dynamics at early and late stages of chronic cardiac disease and before and after clinical intervention.