Case History
A 28-year-old man with a history of neurofibromatosis type 2 (NF2) experienced a five month history of progressive bilateral upper extremity hemiparesis. Neuroimaging studies demonstrated a 4 cm enhancing intramedullary mass located at cervical spinal level 3 (C3).
1) The most common intramedullary spinal neoplasm in this clinical setting is:
- Schwannoma, WHO grade I
- Pilocytic astrocytoma, WHO grade I
- Diffuse astrocytoma, WHO grade II, IDH1 mutant
- Anaplastic astrocytoma, WHO grade III, IDH1 wild-type
- Ependymoma, WHO grade II
2) The characteristic location of the NF2 gene is in chromosome region:
- 22q12
- 2
- 3p25-26
- 9q
- 16p
Answers:
Question 1: E. Ependymoma, WHO grade II
Question 2: B. 2
Case contributed by: Kenneth Fallon, M.D., Associate Professor, Neuropathology