Anna G. Sorace, Ph.D. Awarded NIH R01 Grant
By: Pat Moore
Published Date: Sep 16
Anna G. Sorace, Ph.D.
PI: Anna Sorace
Sponsor: NIH/National Cancer Institute
Title: Personalizing immunotherapy in HER2+ breast cancer through quantitative imaging
Project Period: 3/1/2020 – 2/29/2024 (4) year award
Funding: $1,633,018
Project Narrative:
We propose to integrate advanced—but clinically relevant—imaging with mathematical modeling to personalize, guide, and improve the overall efficacy of anti-HER2 targeted therapy with immunotherapy in murine models of HER2+ breast cancer. Our goal is to provide an approach to exploit the biological and vascular alterations in response to anti-cancer therapies to identify optimal combinations, thereby improving treatment efficacy (while minimizing toxicity) and increasing tumor kill; this has high likelihood to improve patient outcome.
Anna G. Sorace, Ph.D.
PI: Anna Sorace
Sponsor: NIH/National Cancer Institute
Title: Personalizing immunotherapy in HER2+ breast cancer through quantitative imaging
Project Period: 3/1/2020 – 2/29/2024 (4) year award
Funding: $1,633,018
Project Narrative:
We propose to integrate advanced—but clinically relevant—imaging with mathematical modeling to personalize, guide, and improve the overall efficacy of anti-HER2 targeted therapy with immunotherapy in murine models of HER2+ breast cancer. Our goal is to provide an approach to exploit the biological and vascular alterations in response to anti-cancer therapies to identify optimal combinations, thereby improving treatment efficacy (while minimizing toxicity) and increasing tumor kill; this has high likelihood to improve patient outcome.
Suzanne E. Lapi, PhD, (STTR) Awarded NIH/NHLBI Grant
By: Pat Moore
Published Date: Dec 10
Suzanne E. Lapi, PhD (STTR)
Title: GALLIUM 68 TILMANOCEPT FOR PET IMAGING OF ATHEROSCLEROSIS PLAQUES
Grant# 1R41HL147640-01A1
Sponsor: NIH/NHLBI
Period of performance: 09/01/2019 – 08/31/2020
Amount: $225,000
Suzanne E. Lapi, PhD (STTR)Title: GALLIUM 68 TILMANOCEPT FOR PET IMAGING OF ATHEROSCLEROSIS PLAQUES
Grant# 1R41HL147640-01A1
Sponsor: NIH/NHLBI
Period of performance: 09/01/2019 – 08/31/2020
Amount: $225,000
Project Narrative: This project seeks to develop a gallium-68 (68Ga) labeled radiopharmaceutical diagnostic imaging agent, 68Ga-tilmanocept, for positron emission tomography (PET) imaging of atherosclerotic plaques in the walls of arteries and characterization of their inflammatory microenvironments. This project will enable improved risk assessment and monitoring of therapies for individuals at risk for myocardial infarctions (heart attacks) and ischemic strokes, the leading causes of death worldwide. If successful, this project will significantly reduce the catastrophic burdens inflicted upon our society by these conditions.
Suzanne E. Lapi, PhD, awarded NIH subaward on a grant award
By: Pat Moore
Published Date: Dec 10
Suzanne E. Lapi, PhD
Grant Number: 1P01CA221775-01A1
Title: Precision Delivery and Imaging to Enhance Solid Tumor Therapy
Sponsor: NIH/NCI
5 Year subaward totaling: $3,954,322
Suzanne E. Lapi, PhDGrant Number: 1P01CA221775-01A1
Title: Precision Delivery and Imaging to Enhance Solid Tumor Therapy
Sponsor: NIH/NCI
5 Year subaward totaling: $3,954,322
Project Narrative: The overall goal of the proposed research seeks to use imaging strategies to overcome current limitations to effective delivery of antibody-drug conjugates and radioimmunotherapies into solid tumors. This includes the first clinical trial to evaluate a PET-based 89Zr-labeled antibody for tumor imaging that is actively pumped across the tumor endothelium to deliver the highest levels to solid tumors. This Project also provides for a clinical trial to treat metastatic solid tumors, also for the first time, using novel caveolae-targeted drug conjugates.
Harrison Kim, awarded R41 NIH Grant
By: Pat Moore
Published Date: Dec 10
Harrison Kim, PhD, MBA
Grant Number: R41OD027206 (STTR)
Title: A Portable Device for Accurate Mouse Tail Vein Injection
Sponsor: NIH/Small Business Technology Transfer Program
1 Year award totaling $175,264
Harrison Kim, PhD, MBAGrant Number: R41OD027206 (STTR)
Title: A Portable Device for Accurate Mouse Tail Vein Injection
Sponsor: NIH/Small Business Technology Transfer Program
1 Year award totaling $175,264
Project Narrative: The goal of this study is to develop a device to facilitate tail-vein injection in mice (80% or higher yield rate). This device will significantly increase animal welfare as well as improve data quality, while decreasing the total research cost. This device will be a paradigm shift in mouse tail-vein injection for the global preclinical research community.
Harrison Kim, Benjamin Larimer awarded NIH Grants
By: Pat Moore
Published Date: Dec 10
Harrison Kim, PhD, MBA
Grant Number: UG3CA232820
Title: Disposable Perfusion Phantom for Accurate DCE-MRI Measurement of Pancreatic Cancer Therapy Response
Sponsor: NIH/National Cancer Institute
2 Year award totaling $763,402
Project Narrative
Immune checkpoint inhibitors activate the immune system to recognize and attack cancer cells, and have markedly advanced treatment options for patients with a broad variety of cancers. However, standard imaging methods are often not useful in response assessment of immune modulators due to a lack of change in tumor size or metabolic activity with an immune cell infiltrate. To address this unmet clinical and research need, a novel PET imaging approach will be utilized to measure T cell activation within a tumor as a new imaging paradigm for tumoral response evaluation to immune modulators.
Harrison Kim, PhD, MBAGrant Number: UG3CA232820
Title: Disposable Perfusion Phantom for Accurate DCE-MRI Measurement of Pancreatic Cancer Therapy Response
Sponsor: NIH/National Cancer Institute
2 Year award totaling $763,402
Project Narrative
The purpose of this project is to validate a UAB-invented perfusion phantom as a clinical tool to measure pancreatic tumor response to therapy early and accurately in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). During UG3 phase, a disposable perfusion phantom and a data analysis software package will be developed. During UH3 phase, the clinical utility of those will be validated to improve the accuracy of DCE-MRI measurement for early assessment of pancreatic tumor response to therapy.
Benjamin M. Larimer, PhD
Grant Number: R00CA2115604
Title: Quantitative PET Imaging for Oncologic Immune Response Prediction
Sponsor: NIH/National Cancer Institute
3 year award totaling $744,213
The purpose of this project is to validate a UAB-invented perfusion phantom as a clinical tool to measure pancreatic tumor response to therapy early and accurately in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). During UG3 phase, a disposable perfusion phantom and a data analysis software package will be developed. During UH3 phase, the clinical utility of those will be validated to improve the accuracy of DCE-MRI measurement for early assessment of pancreatic tumor response to therapy.
Benjamin M. Larimer, PhDGrant Number: R00CA2115604
Title: Quantitative PET Imaging for Oncologic Immune Response Prediction
Sponsor: NIH/National Cancer Institute
3 year award totaling $744,213
Project Narrative
Immune checkpoint inhibitors activate the immune system to recognize and attack cancer cells, and have markedly advanced treatment options for patients with a broad variety of cancers. However, standard imaging methods are often not useful in response assessment of immune modulators due to a lack of change in tumor size or metabolic activity with an immune cell infiltrate. To address this unmet clinical and research need, a novel PET imaging approach will be utilized to measure T cell activation within a tumor as a new imaging paradigm for tumoral response evaluation to immune modulators.
Canon, Morgan appointed to ABR leadership positions
By: Pat Moore
Published Date: Dec 10
Cheri L. Canon, M.D., Professor and Witten-Stanley Endowed Chair of Radiology at the University of Alabama at Birmingham, has been named to the American Board of Radiology’s Board of Governors. Desiree E. Morgan, M.D., Professor and vice chair for Education in the Department of Radiology at UAB, has been appointed to the American Board of Radiology’s Board of Trustees. Read more>>>
UAB Medicine magazine: Now You See It
By: Pat Moore
Published Date: Sep 10
Multimodal radiological imaging is spurring new perspectives on diagnosis and treatment. Read more about UAB’s state-of-the-art imaging capabilities and cutting-edge research in the latest issue of UAB Medicine magazine. Read more>>
Interventional Radiology Symposium 2018
GME Works for Well-Being Announcement
By: Pat Moore
Published Date: Jul 30
Congratulations to Drs. Elainea Smith, Jessica Zarzour, and AJ Gunn on being awarded the 2018 GME Works for Well-Being! This is an award of financial suppirt for our residents!
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| Elainea N. Smith, M.D. Resident Leader |
Jessica G. Zarzour, M.D. Faculty Co-Mentor |
Andrew J. Gunn, M.D. Faculty Co-Mentor |
In February 2018, the GME Office announced GME Works for Well-Being, a call for proposals with the purpose of mirroring the ACGME’s Back to the Bedside Initiative to increase efforts within our institution to support innovated ideas, clinical practices or policies that will improve physician well-being and foster a sense of meaning in work and can be shared as best practices for all training programs within our institution.
The GME Wellness Subcommittee, chaired by Brenessa Lindeman, MD, Associate DIO for the Clinical Learning Environment, reviewed all submitted applications in May 2018. Based on the selection criteria of project purpose, design, budget, and overall impact, three applications were selected for funding. Award winners were finalized in June 2018. These programs and their projects were awarded financial support from the GME Office that is matched by their respective department. Please see the UAB GME Department wellness web page for available resources to support resident and fellow well-being.
PGY5 Residents, 100% ABR Core Exam Pass Rate
By: Pat Moore
Published Date: Jul 30
Congratulation to the PGY 5 resident class on their 100% ABR Core Exam pass rate this year. We are all so proud of you, and know that you will continue to gain more knowledge as you help care for our patients at UAB through your senior year.
Congratulation to the PGY 5 resident class on their 100% ABR Core Exam pass rate this year. We are all so proud of you, and know that you will continue to gain more knowledge as you help care for our patients at UAB through your senior year.
4th Annual Ready Event Awards 2018
By: Pat Moore
Published Date: Jul 11
| Abdominal Imaging | Breast Imaging | Cardiopulmonary Imaging |
| Dr. Daniel Childers | Dr. Saurabh Gupta | Dr. Benjamin Mullenbach |
| Dr. Noah McGill | ||
| Interventional Radiology | Molecular Imaging & Therapeutics | Musculoskeletal Imaging |
| Dr. Daniel Childers | Dr. Al Sardari | Dr. Elainea Smith |
| Dr. Roberto Valentin | ||
| Neuroradiology Imaging | VA Radiology | |
| Dr. Daniel Childers | Dr. Saurabh Gupta | |
| Dr. Padma Manapragada | Dr. Brenten Heeke | |
| Pitt-Bernreuter Award for Excellent Patient Care: Dr. Melissa Beasley | ||
| Outstanding Fellow Award: Dr. Samuel Galgano & Dr. Jason Henry Williams | ||
| Best Resident Research Award: Dr. Zachary Lambertsen | ||
| RSNA Resident Research Award: Dr. Benjamin L. Triche | ||
Teaching Awards |
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| Best Faculty Board Reviewer Award: Dr. AJ Gunn | ||
| Distinguished Teaching Faculty Award: Dr. Kristin K. Porter | ||
| Medical Student Award for Outstanding Resident Lecturer: Dr. Rachel Bass | ||
| Medical Student Award for Outstanding Faculty Lecturer: Dr. Nina Terry | ||