Project 2: Validating the JAK/STAT Pathway as a Novel Therapeutic Strategy in PD - P50 in Parkinson’s

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Udall Center of Excellence in Parkinson’s Disease Research Heersink School of Medicine

Are inhibitors of the JAK/STAT Signaling Pathway a potential treatment for Parkinson Disease?
- How does -syn lead to activation of the JAK/STAT pathway, and how does this contribute to neuroinflammation and neurodegeneration?
- How is JAK/STAT signaling status altered in peripheral immune cells from PD patients, and how are these changes related to clinical outcomes?
- Can inhibitors of the JAK/STAT pathway prevent neurodegeneration in animal models of PD?