Jeff Hansen

Jeff Hansen

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Research Editor

jeffhans@uab.edu • (205) 209-2355

Communicates UAB research discoveries and initiatives from across the university for a variety of audiences.

Specific beats include: biochemistry; cell, developmental and integrated biology; microbiology; molecular genetics; neurobiology; pathology; pharmacology and tocixology; Alabama Drug Discovery Alliance; Bill L. Harbert Institute for Innovation and Entrepreneurship.

Memory killer T cells are primed in the spleen during influenza infection

This finding upends the long-held paradigm that priming during lung infections takes place only in the draining lymph nodes, and it will be key to developing more efficient vaccinations and therapies for respiratory challenges.

This finding upends the long-held paradigm that priming during lung infections takes place only in the draining lymph nodes, and it will be key to developing more efficient vaccinations and therapies for respiratory challenges.

Dell’Italia honored by VA for decades of research excellence

The John B. Barnwell Award for outstanding achievement in clinical science research is the highest honor of the VA’s Clinical Science Research and Development Service.
The John B. Barnwell Award for outstanding achievement in clinical science research is the highest honor of the VA’s Clinical Science Research and Development Service.

Reversal of lung fibrosis in mouse model suggests a novel therapeutic target for pulmonary fibrosis

A Bcl-2 inhibitor that has FDA approval for treatment of several leukemias reversed lung fibrosis in a bleomycin mouse model.

A Bcl-2 inhibitor that has FDA approval for treatment of several leukemias reversed lung fibrosis in a bleomycin mouse model.

Breast cancer stem cells may use an arteriolar niche to prepare for metastasis

In this arteriolar niche, breast cancer stem cells and arteriolar endothelial cells cross-talk using a well-known signaling pathway. Targeting this pathway may offer therapeutic potential.

In this arteriolar niche, breast cancer stem cells and arteriolar endothelial cells cross-talk using a well-known signaling pathway. Targeting this pathway may offer therapeutic potential.

An existing drug may change tumor-associated macrophages back to cancer fighters

The drug Vismodegib, tested in a breast cancer model, is an inhibitor of hedgehog signaling, a form of cell communication manipulated by the tumor microenvironment.
The drug Vismodegib, tested in a breast cancer model, is an inhibitor of hedgehog signaling, a form of cell communication manipulated by the tumor microenvironment.

A microRNA network is the putative mediator of reductive stress in the heart

Understanding how reductive stress is controlled may help personalize treatment of heart failure patients, leading to better outcomes.

Understanding how reductive stress is controlled may help personalize treatment of heart failure patients, leading to better outcomes.

Ovarian cancer: potential therapeutic target identified

The histone methyltransferase DOT1L — the potential target — is overexpressed in ovarian cancer, and high levels of expression correlate with reduced progression-free and overall survival.
The histone methyltransferase DOT1L — the potential target — is overexpressed in ovarian cancer, and high levels of expression correlate with reduced progression-free and overall survival.

First 3-D view of TB granulomas alters paradigm of their shape and formation

MicroCT of infected human lung tissue, along with histology and immunohistochemistry, was used to construct images of TB granulomas, airways and vasculature.

MicroCT of infected human lung tissue, along with histology and immunohistochemistry, was used to construct images of TB granulomas, airways and vasculature.

Advantages of intranasal vaccination against SARS-CoV-2

Intranasal vaccination is needle-free and elicits immunity at the site of infection, the respiratory tract.
Intranasal vaccination is needle-free and elicits immunity at the site of infection, the respiratory tract.

A small molecule induces readthrough of cystic fibrosis CFTR nonsense mutations

This research suggests that a path to treat currently untreatable cases of cystic fibrosis is clearly achievable.
This research suggests that a path to treat currently untreatable cases of cystic fibrosis is clearly achievable.
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