Jeff Hansen

Jeff Hansen

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Research Editor

jeffhans@uab.edu | (205) 209-2355

Communicates UAB research discoveries and initiatives from across the university for a variety of audiences.

Specific beats: 

  • Alabama Drug Discovery Alliance
  • Biochemistry and Molecular Genetics 
  • Biomatrix Engineering and Regenerative Medicine 
  • Cell biology 
  • Center for Biophysical Sciences and Engineering 
  • CCTS
  • Center for Metabolic Bone Disease 
  • Microbiology 
  • Neurobiology 
  • Comprehensive Neuroscience Center 
  • Pathology, research shared with MS2
  • Pharmacology and Toxicology 
  • Physiology and Biophysics 
  • UAB Research Foundation/IIE 
  • Research Administration
An Arizona drug company will patent the small peptide drug.
Until now, no toxin had been found in 132 years of study for the deadly pathogen Mycobacterium tuberculosis, which infects 9 million people a year and kills more than 1 million. The novel toxin induces necrotic cell death of macrophages to help the tuberculosis pathogen escape and spread to other cells.
The challenge is to stifle the binding of inhibitory antibodies but retain activity of a blood enzyme.
The mimicry of bone cells by multiple myeloma is driven by overexpression of Runx2, the master regulator of bone formation.
The drug inhibits the activity of a kinase enzyme called LRRK2, and it showed no pathology in rat lungs, kidneys or livers.
Best of 2015 2The intensive intervention was four hours a day, five days a week, for a total of 200 hours of face-to-face instruction, and neuroimaging revealed brain connectivity changes.
Macrophage cells require agility to scavenge and digest dead cells and prevent an immune response to self. In lupus, the macrophages lose that agility.
This improvement in cognition persists despite a high-glycemic-index diet, a possible risk factor for Alzheimer’s.

Best of 2015 2Neuron-derived microRNAs obtained from blood samples may correlate with treatment response and could aid the search for new therapeutics.

UAB pathologist also leads a trainee in producing software to improve the quality and efficiency of perinatal autopsies.
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