An overabundance of mast cells, which are important components of the immune system and are produced in the bone marrow, can lead to a variety of health issues.
Chronic pain often leads to depression, which increases suffering and is clinically difficult to treat. Understanding the underlying mechanism identifies a potential therapeutic target for treatment.
The researcher says this proposal will analyze the novel concept that circadian disruption presents an additional challenge to mitochondrial function and liver health in the alcohol consumer.
Diabetic retinopathy is the leading cause of blindness in American adults. The source of this damage may lie in the belly — mainly a leaky small intestine. A novel treatment can possibly prevent or reverse this damage.
Childhood cancer survivors with two genetic variations on the ROBO2 gene and who were treated with high doses of anthracycline treatment have a higher risk of developing cardiomyopathy.
The UALCAN data-mining portal at UAB has been used by cancer clinicians and researchers from more than 100 countries in their search for the molecular basis of cancer.
The spinoff company, IN8bio Inc., uses proprietary drug-resistant immunotherapy licensed in part from UAB. Glioblastoma is the most aggressive type of cancer originating in the brain.
Precision medicine approach may identify those at high genetic risk of hypertension, heart failure, stroke and heart attacks and use precision medicine to help prevent fatal cardiovascular diseases.
This study underscores the vital role of mental health professionals in public health, providing preliminary support for another potential benefit of public health efforts to encourage COVID-19 preventive measures (testing), namely promoting mental health.
The study suggests that BMT survivors were more likely to be unable to afford basic necessities, and to defer medical care, in the wake of the COVID-19 pandemic.
The five-year IPPSE grant will address the critical personnel shortage in education by graduating participants early, making a difference in the lives of P-12 students with disabilities in the Birmingham metro area.
The first large multi-ancestry genetics study of osteoarthritis, or OA, has found 10 novel OA-associated genetic loci, and results showed some of the OA-associated regions are robustly found in every population ancestry studied.
Published findings from UAB suggest that certain firearm laws in one state were associated with other states’ firearm-related deaths. Additionally, permit-to-purchase laws were associated with decreased firearm-related death rates both within a state and nearby states.
Insights that are not possible with conventional two-dimensional platforms include characterization of obliterated airways in tuberculosis and hemorrhage from ruptured blood vessels in COVID-19 lungs, at near-microscopic levels.
UAB researchers have published an article demonstrating how the term “aggressive care,” used loosely by clinicians to describe care that can negatively impact quality of life for patients with serious illness, is often used to inappropriately label the preferences of African American patients.
Experimental neonatal chronic lung disease is marked by a redox imbalance that damages the lungs, and that damage can be ameliorated using a live biotherapeutic mixture of three Lactobacillus species.
Grants totaling more than $3 million have been awarded to UAB researchers in Chemistry and Physics by the Department of Energy, signaling continued investment in UAB projects.
In this cohort study of 19,580 patients with breast cancer, the researchers found that White women who lived in less deprived neighborhoods showed decreased mortality, but that Black women did not.
A UAB study including more than 20,000 ventricular assist device recipients showed that patients diagnosed with familial dilated cardiomyopathy had better clinical outcomes compared with other DCM diagnoses.
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