Research - News
UAB experts highlight the social determinants of obesity and add to the growing body of evidence identifying potential solutions to address obesity and related conditions.
Single-nucleus RNA-sequencing in a newborn pig model showed increased cell cycle activity and proliferation in cardiomyocytes, which helped remuscularize the left ventricle after experimental heart attack.
The grant is being used to fund a first-of-its-kind clinical trial that will recruit healthy individuals through a “genome-first” approach and perform deep metabolic phenotyping to understand the underlying mechanisms responsible for the regulation of the human body’s metabolism through natriuretic peptide hormones.
X-ray crystallography revealed the structure of the HIV-1 matrix protein at 2.1 angstroms resolution, advancing understanding of key mechanisms of viral assembly.
The study revealed that, among critically ill patients undergoing tracheal intubation, fluid bolus administration did not significantly decrease the incidence of cardiovascular collapse.
Vacuuming, mopping, walking a pet or playing catch may be enough activity to avoid a stroke, according to a national study published in JAMA Network Online.
Surprisingly, several competing models for this clathrin-mediated endocytosis all appear to function in two cell lines tested.
To facilitate gene-level queries of data from more than 10,000 cancer patient transcriptome sequences and proteomics data from 2,000 patients, researchers have developed a user-friendly cancer data analysis web platform called UALCAN.
This grant is being used to fund the first-of-its-kind and largest clinical study in the United States to perform deep physiological phenotyping and will exclusively recruit Black adults to study the use of FDA-approved medications and their role in improving cardiometabolic health.
Kidney failure experts recommend new tool that eliminates race as a determining factor for diagnosis
New findings published in the Journal of the American Medical Association show an eGFR equation that excludes race as a coefficient and includes creatine and cystatin C measurements could demonstrate racial differences in the risk of kidney failure requiring dialysis.
The investigators will look at diet’s impact on mobility, physical and cognitive function, as well as on pain, fatigue, sleep, mood and anxiety, in people with multiple sclerosis
The biodegradable nanovehicles accumulated in human breast cancer tumors in mice after systemic injection, and they inhibited oncogene expression and extended survival of the mice.
The $20 million National Science Foundation award will help UAB and eight other Alabama-based universities build research infrastructure. UAB’s share will be about $2 million.
The drug inhibits the kinase Cdk5, found in mature neurons. Cdk5 has long been implicated in neuropsychiatric and neurodegenerative conditions, but previous inhibitors have largely failed to reach the brain through the blood-brain barrier.
This discovery validates siderophore secretion as a drug target in tuberculosis and reveals a new mechanism for putative drugs. Many tuberculosis bacteria are highly resistant to multiple antibiotics.
This novel mode of altering gene silencing boosts the unfolded protein response pathway in the cancer cells, helping those cells survive during rapid growth.
For just the third time in history, a University of Alabama at Birmingham faculty member has been elected to the prestigious National Academy of Sciences.
This therapy, using sustained release of nitric oxide, may be a novel, efficient and safe way to prevent and treat multiple metabolic diseases.
Vohra receives $540k grant from U.S. Department of Energy’s National Nuclear Security Administration
A UAB physics professor has received a grant to synthesize novel materials for hypersonic applications and study their response under extreme conditions.
An absence of sub-strain variation over a short period was seen in sick patients, which may signal impending gut dysbiosis.
This study included three lines of human cancer cells and suggests new potential therapeutic targets in cancer.
UAB is the only site in the state of Alabama to perform brachytherapy treatment.
The distinct cell populations were identified by single-nucleus RNA sequencing of 21,600 cells of the rat ventral tegmental area, located in the midbrain.
The investigational drug masitinib appears to inhibit parts of the immune system that may be overactive in ALS.
The UAB Cardiogenomics Clinic provides genetic testing and counseling for a gene variant associated with a risk of heart failure and death.
Researchers show how two types of immune cells — one a part of the innate immune system and the other a part of the adaptive immune system — play distinct and indispensable roles in the colon to defend against pathogenic bacteria.
UAB researchers analyze the role that natriuretic peptides play in high nighttime blood pressure.
This genetic risk score may help health care providers identify the risk of heart disease earlier and take preventive measures.
COVID-related acute kidney injury peaked in 10- to 15-year-olds and 70- to 75-year-olds, suggesting age is not the sole determinant in severity of illness from COVID-19.
Researchers have been awarded a $2.6 million, four-year National Institutes of Health grant to evaluate a safer and more durable stent design, using techniques licensed through the UAB Harbert Institute for Innovation and Entrepreneurship by the UAB spinoff company Endomimetics LLC.