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20-year analysis shows increase in in-hospital cardiac arrests despite advances in resuscitation medicine

20-year analysis shows increase in in-hospital cardiac arrests despite advances in resuscitation medicine
As overall in-hospital cardiac arrest rates rise, overall survival rates are improving in tandem. But researchers say there is still room for improvement.

Heart disease in black individuals: Two elevated biomarkers distinguish Blacks with resistant hypertension from whites

Heart disease in black individuals: Two elevated biomarkers distinguish Blacks with resistant hypertension from whites
Blacks face much greater rates of heart disease than do whites. A wider study is needed to further investigate this racial difference and identify potential therapeutic targets.

School of Dentistry to have a major impact upon future care of oral health nationwide

School of Dentistry to have a major impact upon future care of oral health nationwide
UAB researchers are contributing to “Oral Health in America: Advances and Challenges,” a national publication aimed at exploring the nation’s oral health over two decades.

Distinct structural domains in MUNC long non-coding RNA regulate gene expression

Distinct structural domains in MUNC long non-coding RNA regulate gene expression
Anindya Dutta, M.D., Ph.D., and colleagues now have detailed the first structure-function study of this long non-coding RNA.

Hardiman awarded $1.9 million R01 to study gastrointestinal cancer

Hardiman awarded $1.9 million R01 to study gastrointestinal cancer
Although combination chemotherapy with radiation has been the standard of care for treating rectal cancer for more than 20 years, very little is known about why some tumors are more resistant to this treatment than others.

COVID-19 breakthroughs, personalized medicine at scale and thousands of quality jobs in Birmingham: Southern Research prepares for its next 80 years

COVID-19 breakthroughs, personalized medicine at scale and thousands of quality jobs in Birmingham: Southern Research prepares for its next 80 years
Southern Research has 400 full-time employees, brings in $80 million in revenue and has an annual economic impact of $150 million.

Race and insurance-status played role in decline of pediatric emergency department visits during 2020

Race and insurance-status played role in decline of pediatric emergency department visits during 2020
Throughout 2020, the decline in pediatric emergency department visits among Black and public or self-insured patients was consistently larger than other demographics.

Pig kidneys to humans: next steps for the UAB xenotransplantation program

Pig kidneys to humans: next steps for the UAB xenotransplantation program
UAB physicians are working on the next steps to begin compassionate or emergency use of the pig kidneys in living humans. Two major approvals will be required.

Boosting the immune defense: interleukin-2 promotes fate decisions in CD8 T cells for long- or short-term immune protection

Boosting the immune defense: interleukin-2 promotes fate decisions in CD8 T cells for long- or short-term immune protection
In response to a viral infection, intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling, leading to different fates for two subsets of those cells — the one producing IL-2 and the one not producing IL-2.

UAB Chronic Hypertension and Pregnancy trial receives $12.8 million for follow-up and preeclampsia epigenetics studies

UAB Chronic Hypertension and Pregnancy trial receives $12.8 million for follow-up and preeclampsia epigenetics studies
Consortium led by UAB researchers in the UAB Heersink School of Medicine and School of Public Health received additional funding to further study chronic hypertension and preeclampsia epigenetics participants enrolled in the CHAP trial.

UAB one of eight recipients awarded STEM-capable workforce grant by U.S. Economic Development Administration

UAB one of eight recipients awarded STEM-capable workforce grant by U.S. Economic Development Administration
A $200,000 grant for Magic City Data Collective will continue to build a diverse pipeline between students with data analysis skillets and local private-sector job opportunities.

An NICU quality-improvement program reduced death or severe brain bleeding in extremely premature infants

An NICU quality-improvement program reduced death or severe brain bleeding in extremely premature infants
Death or severe brain bleeding in the first week after birth dropped from 27.4 percent to 15 percent after introduction of a bundle of evidence-based, potentially better practices for preterm infants. Median weight of the 820 infants studied was 1 pound, 10 ounces.

Weight loss may take longer than expected due to metabolic adaptation

Weight loss may take longer than expected due to metabolic adaptation
The findings represent the first study to examine whether metabolic adaptation, at the level of Resting Metabolic Rate (RMR), is associated with time to reach weight-loss goals.

Research internships prepare students for academic and career success in STEM fields, study shows

Research internships prepare students for academic and career success in STEM fields, study shows
Early research internships allow students to discover careers of interest they may not otherwise experience, providing an effective way to set them up for success, study suggests.

Study supports virotherapy as a potential treatment for brain tumors

Study supports virotherapy as a potential treatment for brain tumors

A new study confirms that G207, a genetically engineered virus developed at UAB, may be a beneficial therapy for brain tumors.

Bibb receives $1.2 million neuroendocrine cancer research award

Bibb receives $1.2 million neuroendocrine cancer research award
Bibb has been studying neuroendocrine cancer for almost 10 years and has published several reports in high-impact scientific journals.

Hill receives funding for NIH precision nutrition study

Hill receives funding for NIH precision nutrition study
UAB is one of 14 institutions receiving funding for the Nutrition for Precision Health Study, part of the NIH’s All of Us Research Program.

The 10-gene pig and other medical science advances enabled UAB’s transplant of a pig kidney into a brain-dead human recipient

The 10-gene pig and other medical science advances enabled UAB’s transplant of a pig kidney into a brain-dead human recipient
The human preclinical model at UAB provides important knowledge before a Phase I clinical trial can begin for living human recipients. Decades of work by researchers across the world preceded UAB’s first clinical-grade pig kidney xenotransplant.

How LPS prevents or promotes development of asthma and allergic disease by airborne allergens

How LPS prevents or promotes development of asthma and allergic disease by airborne allergens

A detailed mechanistic study unravels how the bacterial endotoxin LPS prevents or promotes allergic disease.

Why customer returns are causing companies to lose money

Why customer returns are causing companies to lose money
UAB researcher explains why retailers prefer customers to keep purchased items instead of returning.

Target identified to improve immunotherapy against solid tumors: the transcription factor Blimp1

Target identified to improve immunotherapy against solid tumors: the transcription factor Blimp1

Disruption of Blimp1 in regulatory T cells remodels the tumor microenvironment and augments the response to immunotherapy.

New gene therapy could provide cure for sickle cell disease, according to UAB study

New gene therapy could provide cure for sickle cell disease, according to UAB study

Although unproven, this novel sickle cell therapy serves as a potential cure. More measures need to be taken to determine long-term function and organ improvement.

$2.1 million grant seeks to identify potential therapeutic strategy for Alzheimer’s disease

$2.1 million grant seeks to identify potential therapeutic strategy for Alzheimer’s disease
Research outcomes from a newly funded study could aid in the development of novel therapeutic strategies for Alzheimer’s.

Consumption behavior identifies boy-girl gender discrimination in Chinese households

Consumption behavior identifies boy-girl gender discrimination in Chinese households
Zhang’s research compares clothing expenditures between boys versus girls using a rich, household-specific data set.

Gel to improve development of an arteriovenous fistula holds promise for kidney-dialysis patient care

Research in animal models shows better formation of the fistulas, which are a lifeline for kidney failure patients as the connection site to dialysis machines.
Research in animal models shows better formation of the fistulas, which are a lifeline for kidney failure patients as the connection site to dialysis machines.

Cancer-fighting spinoff from UAB grows through IPO, clinical trial and new lab space in Birmingham

At UAB, the company IN8bio Inc. is running a Phase I clinical trial to treat glioblastoma multiforme, the most aggressive type of cancer that originates in the brain.

At UAB, the company IN8bio Inc. is running a Phase I clinical trial to treat glioblastoma multiforme, the most aggressive type of cancer that originates in the brain.

UAB part of nationwide study on Parkinson’s disease

UAB part of nationwide study on Parkinson’s disease

The PPMI study is looking for biomarkers for Parkinson’s disease, which would help identify those at risk and track the progression of the disease.

UAB, Morehouse School of Medicine and Tuskegee University receive $18 million grant to reduce cancer disparities

UAB O’Neal Comprehensive Cancer Center, Morehouse School of Medicine and Tuskegee University collectively receive $18 million U54 grant from the National Cancer Institute.

UAB O’Neal Comprehensive Cancer Center, Morehouse School of Medicine and Tuskegee University collectively receive $18 million U54 grant from the National Cancer Institute.

UAB researcher shines light on a rare disease that causes developmental and intellectual delays

After years of researching the SON gene, Erin Eun-Young Ahn, Ph.D., may have found the cause behind an extremely rare disease.

After years of researching the SON gene, Erin Eun-Young Ahn, Ph.D., may have found the cause behind an extremely rare disease. 

UAB to study whether exercise can boost memory in people with epilepsy

UAB to study whether exercise can boost memory in people with epilepsy

Recent studies have shown that formal exercise training can help boost memory, and memory deficit is relatively common in people with epilepsy.

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