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UAB will test a COVID-19 vaccine candidate created by Altimmune Inc.

UAB will test a COVID-19 vaccine candidate created by Altimmune Inc.
The testing at UAB will investigate immune responses to the vaccine in mice — an important step before any Phase 1 human safety trial in patients later this year.

UAB among U.S. sites hosting new clinical trial for COVID-19 treatment

UAB among U.S. sites hosting new clinical trial for COVID-19 treatment

UAB is playing a key role in the effort to expedite clinical trials to combat COVID-19.

The director of NIH visits UAB as COVID-19 appears

The director of NIH visits UAB as COVID-19 appears

Francis Collins, M.D., Ph.D., visited UAB just as COVID-19 appeared near the NIH.

Nonfatal overdose is common among veterans who experience homelessness

Nonfatal overdose is common among veterans who experience homelessness

The study showed that 7.4 percent of veterans with a history of homelessness reported having an overdose in the past 3 years. Alcohol was the most commonly involved substance, but opioids and other drugs were common.

UAB Pathology to increase COVID-19 testing by week’s end

UAB Pathology to increase COVID-19 testing by week’s end
UAB researchers are now running tests and will soon have them available on a commercial platform, increasing output.

COVID-19: Do not forget the host in treating this disease

COVID-19: Do not forget the host in treating this disease

An immune reaction to COVID-19 infection called cytokine storm syndrome can be fatal to COVID-19 patients.

Carb-restricted diet may result in benefits for adolescents with fatty liver disease

Carb-restricted diet may result in benefits for adolescents with fatty liver disease
The study observed two diet types to test their impact on adolescents with non-alcoholic fatty liver disease.

Genes may predict cancer patients at highest risk of chemo brain after BMT

Genes may predict cancer patients at highest risk of chemo brain after BMT
In the first study of its kind, researchers identified genetic factors that can lead to a decrease in cognitive ability after a blood or bone marrow transplant.

Examining racial bias in cancer research trials

Examining racial bias in cancer research trials
The study uncovered bias and stereotyping when recruiting patients for clinical trials.

Hydrogen sulfide heightens disease in tuberculosis, suggesting a new therapeutic target

Hydrogen sulfide heightens disease in tuberculosis, suggesting a new therapeutic target

The tuberculosis bacteria induce increased hydrogen sulfide production by human macrophages, which increases pathogenesis.

Cellular metabolism regulates the fate decision between pathogenic and regulatory T cells

Cellular metabolism regulates the fate decision between pathogenic and regulatory T cells
Manipulating cellular metabolism may provide a promising therapeutic intervention in autoimmune diseases.

Telecommunicator CPR can save lives following cardiac arrest

Telecommunicator CPR can save lives following cardiac arrest
Telecommunicator CPR, guidance and assistance from 911 dispatchers can help 911 callers save lives.

Lipid signaling from beta cells can potentiate an inflammatory macrophage polarization

Lipid signaling from beta cells can potentiate an inflammatory macrophage polarization
This suggests the possibility of cross-talk that heightens pathogenesis in Type 1 diabetes.

Spending childhood, early adulthood in Stroke Belt increases risk of developing cognitive impairment later in life

Spending childhood, early adulthood in Stroke Belt increases risk of developing cognitive impairment later in life
People who spent their childhood or early adulthood in the Stroke Belt are more likely to develop cognitive impairment later, even if they have moved away.

Study shows new surgical protective gear does not reduce surgical site infections

Study shows new surgical protective gear does not reduce surgical site infections
New guidelines for operating room attire to prevent surgical site infections may be ineffective.

New pathogenic mechanism for influenza NS1 protein found

New pathogenic mechanism for influenza NS1 protein found
Influenza NS1 can bind with the cell’s RIG-I protein, blocking the innate immune response

New study calculates damage of food and lifestyle choices on inflammation

New study calculates damage of food and lifestyle choices on inflammation
A study of ice and fire: Research by UAB nutritional epidemiologist Suzanne Judd, Ph.D., and colleagues identified 19 foods and four lifestyle elements that raise or lower inflammation.

UAB injury study charts the unknown: Ultimate Frisbee

UAB injury study charts the unknown: Ultimate Frisbee
A UAB study of injury rates sustained by professional Ultimate players lays the groundwork for better understanding of injury risk as well as prevention strategies for the sport.

Holistic benefits of play in the classroom article among the journal’s best in 2019

Holistic benefits of play in the classroom article among the journal’s best in 2019

An article highlighting the importance of play in a child’s education and development selected as the 2019 Most Outstanding Article by journal.

How a community’s built environment impacts physical, mental health

How a community’s built environment impacts physical, mental health
Students are examining 60 variables, including sidewalk conditions, crosswalks, blighted properties and advertisements in four Birmingham communities.

Link between chronic kidney disease and heart failure is identified in patients

Link between chronic kidney disease and heart failure is identified in patients
Coronary microvascular dysfunction is a precursor to later heart disease, heart failure and possible death.

Study shows huge fluctuations in the cost of orthobiologics

Study shows huge fluctuations in the cost of orthobiologics
UAB orthopaedic surgeons report that the cost of orthobiologics, promising but not fully proven therapies, can vary widely across the nation.

Unrecognized genetic variation in research mouse models can affect immune cells

Unrecognized genetic variation in research mouse models can affect immune cells
Unsuspected genetic variation among strains of mice can surreptitiously confound data results.

Human fetal lungs harbor a microbiome signature

Human fetal lungs harbor a microbiome signature
This microbiome signature suggests that bacteria, or bacterial products, colonize the lungs far before birth.

Pathogenic Alzheimer’s disease cascade is activated by faulty norepinephrine signaling

Pathogenic Alzheimer’s disease cascade is activated by faulty norepinephrine signaling

Study points to a potential immediate treatment for this devastating disease.

Persistence of gut microbial strains in twins, living apart after cohabitating for decades

Persistence of gut microbial strains in twins, living apart after cohabitating for decades
A genomics tool can determine whether twins maintained identical gut strains, even after living apart for years.

Privacy alert: Brainwave devices can leak sensitive medical conditions and personal information

Privacy alert: Brainwave devices can leak sensitive medical conditions and personal information
Research results show that brain-computer interfaces is one source of caused leaked medical and personal information among particular individuals.

Cancer therapy may be aided by induced macropinocytosis, a rarely reported form of cell death

Cancer therapy may be aided by induced macropinocytosis, a rarely reported form of cell death

In preclinical experiments, a metabolic inhibitor killed a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues.

75 million-year-old sea turtle fossil discovery is a new genus and species that sheds light on the evolution of its modern relatives

75 million-year-old sea turtle fossil discovery is a new genus and species that sheds light on the evolution of its modern relatives
Scientists are racing to determine which genealogy most accurately represents the evolutionary history of sea turtles — a challenging proposition.

Pediatric brain tumor treatment at UAB awarded FDA grant for first-in-human study

Pediatric brain tumor treatment at UAB awarded FDA grant for first-in-human study

A UAB pediatric oncologist will conduct a first-in-human immunovirotherapy study of an oncolytic herpes virus inoculated in the cerebellum.

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