Research - News
This advance should facilitate atherosclerosis drug discovery and development.
The site-directed addition of a polymer on the antibody trastuzumab helped this cancer-fighting antibody cross the blood-brain barrier.
As there is no current treatment for acute and recurrent acute pancreatitis, Dudeja hopes this grant will provide hope for those suffering with the disease.
New findings from UAB researchers indicates that preventable environmental factors like repeated blows to the head in contact sports and pesticides and herbicides account for a substantial number of Parkinson’s disease cases.
These immune CD8 T cells may provide a target for treating the buildup of fatty lesions in the arteries called atherosclerosis.
While it has long been thought that the most direct health effect linked to the sanitation crisis in the Black Belt was due to soil-transmitted hookworm, a study led by UAB found no evidence of transmission.
Vaccination of neonatal mice with group A Streptococcus promotes clonal expansion of B cells that produce antibody against GlcNAc. The association of reduced Type 1 diabetes risk after group A Streptococcus infection is dependent on these GlcNAc-specific B cells.
This is the largest grant the Department of Political Science and Public Administration has received.
The research team’s goal is to create a customizable solution that can be applied across various health care settings to reduce overcrowding in emergency departments.
Tuberculosis, the world’s leading infectious disease killer, caused 1.6 million deaths in 2021, along with 10 million new cases of tuberculosis every year.
The study found that 70-75 percent of all participants, regardless of whether they were already on blood pressure medications or not, were likely to see a reduction in their blood pressure if they lowered the sodium in their diet.
This record-breaking funding marks a 73 percent growth in research awards over nine years.
Vascular stiffening and calcification, which is accelerated by aging, affects multiple organs and plays a role in dementia. There are no treatments for vascular calcification, which makes arteries harden.
The model may provide novel insights into RP59 disease mechanism that will guide future testing of therapeutic interventions.
UAB researchers leverage All of Us Research Program nationwide data from a diverse group of individuals to show that the genetic risk of hypertension varied between males and females.
Researchers have identified a gut-lung axis driven by intestinal antimicrobial peptide expression and mediated by the intestinal microbiota that is linked to lung injury in newborns.
Project TransTeam Evolution strives to improve outcomes for young children with high-intensity needs and their families through evidence-based practices and advance equity for children from diverse cultural, structural and socioeconomic backgrounds.
UAB researchers say this study underscores the significance of addressing food insecurity among college students, not only for its direct impact on BMI but also for its indirect effects on diet habits and psychological well-being.
The world’s first clinical trial of Resuscitative Endovascular Balloon Occlusion of the Aorta found that patients treated with REBOA were more likely to die than those who did not undergo REBOA.
Researchers found 19 Bacteroides vulgatus genes that were unique to three strains that show early engraftment in patients after a fecal transplant, as opposed to seven strains that did not show early engraftment. Most transplant failures occur in the first four weeks.
UAB researchers conducted a landmark study that established the reference intervals for natriuretic peptides — hormones that regulate a range of beneficial bodily functions — and revealed that natriuretic peptide deficiency increases the risk of cardiometabolic diseases.
Cong’s research indicates the increased vulnerability of older adults to climate change impacts while also highlighting their resilience capacity in the face of disasters, offering valuable insights for policy development and disaster preparedness.
Analysis of a survey of 18,041 people in rural KwaZulu-Natal revealed a discrepancy between the ability of the South African health system to respond to the health needs of people with communicable diseases and the health needs of people with non-communicable diseases.
This new grant will be used to develop a full-scale family of devices for inhaled nitric oxide delivery for patients with pulmonary hypertension that can be used in health care facilities and for at-home care.
The Blazer Bridge Fund is intended to identify and assist in the development of promising ideas, discoveries, innovations and/or technologies from UAB faculty and staff that have commercial potential.
UAB researchers conducted a study in end-stage heart failure patients with cardiogenic shock that revealed that B-type natriuretic peptide levels were elevated in end-stage heart failure but did not predict clinical outcomes.
Lung-resident memory B cells produced during influenza are long-living immune cells that migrate to the lungs from draining lymph nodes and lie in wait as early responders that can quickly react to future infections. They are key sentinels against subsequent viral variants.
The M.D./Ph.D. student has since moved on to clinical studies, but the research into possible drugs to treat Alzheimer’s disease continues.
The modified mRNA — delivered after experimental heart attacks — transiently allows heart muscle cells to proliferate, leading to reduced infarct size and improved heart performance compared to untreated animals.
While preventive treatment with vigabatrin delayed the onset and prevalence of infantile spasms in TSC infants, it had no impact on focal seizures, drug-resistant epilepsy, or improvement of cognitive and behavioral scores at 24 months.