Hui Hu Lab
Hosting: Information Session & Interview Room
Department: Microbiology
Lab Description
Hu's lab is a dynamic research group dedicated to investigating the fundamental mechanisms of immune responses. With a team of eight members — including three PhD students, two research assistants, and three undergraduate researchers — the lab explores key questions in immunology using viral infection and tumor models. By integrating cutting-edge experimental approaches, the team aims to uncover novel insights into how the immune system responds to challenges, ultimately contributing to advancements in therapeutic strategies.
Applicant Information
Hu's lab research interest lies in the regulation of Tfh cell differentiation and humoral immune responses. Tfh cells are essential for germinal center formation and long-lived, high-affinity antibody responses. In this research direction, the lab's goals are to identify novel genes and pathways involved in Tfh cell differentiation. The lab is also interested in tertiary lymphoid structure (TLS) in tumors. In this research direction, with their unique experimental tools and insights in Tfh cell differentiation, the lab aims to elucidate the cellular and molecular mechanisms underlying TLS formation and function in tumors. Lastly, the lab is interested in generation and maintenance of stem-like memory CD8+ T cells in infection and tumor models. In this research direction, the lab aims to elucidate the cellular and molecular mechanisms underlying the generation and maintenance of stem-like CD8+ T cells in viral infection and tumor models. In addition, the lab has a long-term interest in developing new CAR-T immunotherapies.
Fun Fact about the PI
Hu's lab members have a strong appreciation for good food, making it a central part of their gatherings. Outdoor activities are no exception — good food is always part of the plan!