You may be eligible to participate in a research study looking at the effects of sacubitril/valsartan on how your body handles insulin and glucose. This medication is related to blood pressure. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart problems, or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated $675 for completing all the visits. To participate, please contact Haley at 205-975-5825 or email us at nauticalstudy@uabmc.edu.

Beginning Oct. 5, the righ-thand turn lane from eastbound University Boulevard onto 18th Street South will be closed until further notice as renovations begin in Unity Park. The southern travel lane may also experience occasional, temporary closures during construction work periods; right-hand turns onto 18th will remain possible.

Adult Volunteers ages 18-75 are needed for a study examining the relationship between oxalate handling in the blood and urine in persons with and without chronic kidney disease. The study involves consuming prepared meals over 5 days twice, one-day long visit in our clinical research unit, and the collection of urine and blood. Compensation up to $360. For more information, call 205-224-7324 or email kidneystoneresearch@uabmc.edu.

Healthy individuals ages 18-75 are needed for a study examining the relationship between oxalate handling in the blood and urine in persons with and without chronic kidney disease. The study involves consuming prepared meals over 5 days twice, one-day long visit in our clinical research unit, and the collection of urine and blood. Compensation up to $360. For more information, call 205-224-7324 or email kidneystoneresearch@uabmc.edu.

Do you have a loved one with agitation associated with Alzheimer’s dementia? Is their agitation becoming overwhelming? Examples of some easily identifiable agitated behaviors are: restlessness, screaming, shouting, throwing things, resistiveness, constant unwarranted requests for attention or help, pacing/aimless wandering, kicking, hitting others or self, pushing people, hurting self or others, tearing things or destroying property. In this study, researchers want to find out if an investigational drug called AVP-786 is safe and effective (useful) in managing agitation in adults with Alzheimer’s dementia, when compared to a placebo. If you are a caregiver for a person with Alzheimer’s disease, please call (205) 996-5987 or email lalexander@uabmc.edu for more information.

If you’re being treated for MDD and your current antidepressant medication(s) is not working, the SAVITRI Study might interest you. The SAVITRI Study is researching a potential MDD therapy to improve symptoms of depression, and you may be able to participate. This research study is now enrolling adults diagnosed with MDD. Those who qualify will receive the investigational medication (or placebo), study-specific medical exams, and study-specific laboratory tests at no cost. Participants in the SAVITRI Study must: be 18 to 65 years of age; have a clinical diagnosis of MDD; be currently on antidepressant medication(s); have had inadequate response to up to 5 oral antidepressant medications; and fulfill other eligibility criteria. For more information, please call (205) 996-5987 or email lalexander@uabmc.edu. Please mention SAVITRI in your message.

Help us find out by joining our study at UAB You may be eligible to participate in the PRECISION-BP research study about the effects of Sacubitril/Valsartan or Valsartan on your body’s 24-hour rhythm of a hormone in your blood called natriuretic peptides. This hormone and the study medications are related to the heart. Eligible participants must be obese (BMI: 30-45 kg/m2) men and women, have high blood pressure, and have no history of heart or kidney problems. The study involves wearing a blood pressure monitor for 24 hours, 24-hour inpatient visits at UAB hospital, taking medications, and collecting blood and urine samples. Meals will be provided at no cost. Participants will be compensated $575 for completing the study visits. Please e-mail Nehal at PRECISION-BPSTUDY@uabmc.edu or call us at 205-934-7173 if you are interested

The Kids Low Vision and Reading (KLoVR) study aims to better understand reading ability among children with permanent vision impairment. We need to recruit children ages 6 to 16 with normal vision (glasses are ok) for a comparison group. Testing includes vision testing, reading tests and memory tests and lasts 2 to 2.5 hours. No eyedrops are used. Participants are compensated with a $100 gift card and free parking in the Callahan Eye Hospital parking deck. Please call the Clinical Research Coordinator, Caroline Durena, in the Center for Low Vision and Rehabilitation at (205)488-0788 for more infor‐ mation about the study and to see if you qualify. This study is funded by the National Institute for Disability, Independent Living and Rehabilitation Research.

If you are currently pregnant, 18 or older, planning to deliver at UAB, and planning to breast feed, you may be eligible for our study. This study focuses on better understanding CMV, a common virus most people in the US are infected with by adulthood, its transmission through breast milk from mother to baby, and how the body protects itself from the virus. Participants will meet with study staff once a month for six months to collect non-invasive samples and answer a questionnaire. Samples collected include oral swabs from you and your baby, a small quantity of breast milk and a skin swab from you, and a urine and stool sample from your baby. Participants will be compensated up to $300 for completing the study visits and providing samples. Eligible participants may also qualify for additional sub-studies for additional compensation up to $800. For more information, please contact Amanda Rafferty at 205-975-3752 or email amrafferty@uabmc.edu.

We are looking for current pessary users to trial a new investigational pessary, which may be more comfortable and easier to use than your current pessary. Participants will be asked to: Continue to wear your current pessary for 1 month Be willing to use a study pessary for 3 months Attend 1-2 visits (at no cost to you) in addition to your pessary usual care Participants will receive: $300 ($100 gift card given for each extra visit and then at the end of the study) For more information call 205-934-5498