UAB S10 Shared Instrument Grant and High-End Instrument Grant Process

Last updated: 1:25 pm, Feb. 16, 2026

To assist UAB investigators in submitting competitive and successful NIH S10 Shared Instrumentation Grants (Shared Instrumentation Grant Program (SIG)) and High End Instrumentation (High-End Instrumentation Grant Program (HEI)) grants, a pre-submission and review process will be followed in 2026. The goal is to assist investigators in proposal development as well as obtaining institutional support necessary for submission. The process will include a letter of intent followed by a merit-based assessment of each project. Both the SIG and HEI have a due date of June 1, 2026.

NIH S10 Program Website

Letter of Intent Components

(2 Pages + 1 Table)

• Page One
  • Principal Investigator
  • Mechanism: Shared Instrument ($50K to $600K) OR High-End Instrument ($601K to $2M)
  • Application Title
  • Equipment make and model + cost estimate/vendor quote
  • Oversight Committee members proposed or actual. (Oversight committees are required for the S10 mechanism)
  • Summary of equipment need/Specific Aims
• Page Two
  • Brief half-page Administrative Plan: in an existing core, department, center or stand-alone (RFA strongly recommends existing cores)
  • Brief half-page financial sustainability plan
• Page Three
  Proposed Users Table including School/College, Department, and grants the instrument would support:

  User (Faculty Member)	School / College	Dept.	Supported Grant (Award #)

The IRCP Director, James Kobie, (This email address is being protected from spambots. You need JavaScript enabled to view it.) will be available until the LOI deadline for consultation and assistance with LOI materials development.

Selected projects will work with the IRCP director to identify and garner Letters of Support along with resource commitments.

It is recommended that each application go through the CCTS-facilitated Instrument Grant Panel before being submitted to OSP.