This laboratory provides state-of-the-art infrastructure for the determination of the energetics of the interactions, and changes in physical properties of the components on forming the complexes. This is achieved using a variety of biophysical methods including calorimetry. Instruments include two MicroCal isothermal calorimeters and one Microcal differential scanning calorimeter.

The biophysical spectroscopy laboratory has state-of-the-art optical spectroscopy instrumentation that is used for a variety of chemical and biochemical research projects. Many of these instruments include automated accessories with temperature control.

• Aviv 400 Circular Dichroism Spectrometer
• Jasco J-815 Circular Dichroism Spectrometer
• JascoFP-6500 Fluorimeter
• Varian-Cary Eclipse Fluorescence Spectrofluorometer
• Bruker Vertex 70 Infrared Spectrometer
• Bomem MB104 Infrared Spectrometer
• Varian-Cary 100 UV-Vis Spectrophotometers
• Varian-Cary 50 Bio UV-Vis Spectrophotometers

The Mass Spectrometry Laboratory employs one full-time supervisor to provide technical assistance, training, and maintenance of the mass spectroscopy instruments. The facility houses the following spectrometers:

• Applied Biosystems/MSD Sciex 4000 Q-Trap - The Q-Trap 4000 is an LC/MS/MS system that offers state-of-the-art hybrid triple quadrupole/Linear Ion Trap sensitivity and ease-of-use, plus triple quad selectivity. This instrument can be interfaced to either a Shimadzu LC system with 96 well autosampler or a DART (Direct Analysis in Real Time) ion source.
• Bruker Autoflex SPEED MALDI-TOF/TOF-MS - This instrument is designed and optimized for ease of use for both traditional MALDI applications, such as protein/peptide characterization, and polymer analysis, as well as high resolution MALDI tissue Imaging, glycan analysis, or high-throughput microbial identification.

Facilities available for conducting research on polymer materials include: Polymer Materials Synthesis; Polymer Molecular and Physical Characterization; and Ultrathin film Materials. The Nanomaterials/Surface Characterization Facility is available to UAB researchers, government users, users from other universities, and industrial customers. We provide nanomaterials/surface characterization services including consultation, data collection, and data processing. These state-of-the-art instruments allow for measurements in bulk and at the nanoscale in situ with temperature control.

• Woollam M2000-U (J. A. Woollam Co., Inc.) multi-angle spectroscopic ellipsometer (240-1000 nm)
• Zetasizer Nano (Nano ZS, Malvern) particle analyser
• Waters GPC-HPLC Breeze 2 system with RI detector
• Theta Lite Optical Tensiometer TL100 (Biolin Scientific)
• A Bruker FT-IR spectrometer (Vertex 70)

The Small Molecule NMR facility provides complete NMR services including consultation, user training, sample preparation, data collection and processing, and data interpretation. The facility includes two Bruker 400 MHz NMR systems and a Bruker 300 MHz system.

The Bruker AXS APEX II SmartBREEZE X-ray Diffractometer is used for determining structures of both small molecules as well as proteins and nucleic acids. This diffractometer is used both for research and training of postdoctoral researchers, graduate students, and is actively used by our undergraduate majors as well.

High resolution mass spectrometry of small molecules and biological samples.

This facility houses four state-of-the-art Bruker NMR spectrometers of varying field strengths: 850 MHz, 700 MHz, 600 MHz, and 500 MHz. The facility provides NMR support to researchers working in the areas of synthetic chemistry, drug design, and structural biology.

Located in the Department of Computer Science, this facility is available to those interested in computer graphics, solid modeling, and fast prototyping.

Provides cell sorting and analytical flow cytometry services.

Standard and next generation sequencing, custom genotyping, gene expression, and whole genome assays.

Provides state-of-the-art imaging resources. Light microscopy instruments include both 2D and 3D laser confocal microscopes. Electron microscopy instruments include both SEM and TEM.

Clinical and pre-clinical applications of mass spectrometry in the areas of proteomics and bioanalytical techniques.

This facility provides access to state-of-the-art X-ray crystallography, NMR, biophysical instrumentation, and computer modeling capabilities for UAB researchers.

Quantitative analysis of small molecules and selected peptides using 2-D electrophoresis, MALDI-TOF, and ESI.