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CDAC Graduate Student Spencer Smith, along with CDAC Academic Partner Yogesh Vohra and colleagues from the University of Alabama - Birmingham, used diamond anvil cell technology, Raman spectroscopy, synchrotron x-ray diffraction, and multiple ab initio harmonic frequency calculations to explore the solid-state transition behavior of Paracetamol (a commonly used analgesic and anti-pyretic) at hydrostatic pressures up to 21 GPa.
Spectral measurements provide further evidence for a highly kinetically driven Form I --> II transition occurring as a mixed phase from 4.8 to 6.5 GPa, as well as new evidence for previously unobserved Form IV and Form V occurring at pressures of 8.1 and 11 GPa, respectively.
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![SSmithJPCA2014Fig2](/cas/news/images/images/physics/SSmithJPCA2014Fig2.jpg)