The Informatics Gateway is an enterprise-wide forum for collaborative project development. The Gateway gathers experts in the appropriate area of informatics, along with biostatisticians, methodologists, and clinical and translational scientists, to help investigators explore novel research directions (for a list of the core members on our Gateway team and to learn more about this unique collaborative opportunity, see our Informatics Gateway poster). To submit a project idea for consideration, fill in our Informatics Gateway Request Form or contact CCTS Research Commons at
Dr. Emmy Bell, UAB
Dr. Jake Chen, UAB
Dr. Chinenye Dike UAB
Dr. Simon Greler, University of South Alabama
Dr. Soumya Niranjan, UAB
Dr. Meredith Reid, Auburn University
2022
Dr. Annabelle Fonseca, University of South Alabama
Dr. Byron Lai, UAB
Dr. Chad Rose, Auburn University
Dr. Henry Zelada Castro, UAB
Dr. Jaimie Roper, Auburn University
Dr. Mohamed Shaban, University of South Alabama
2021
Dr. Courtney Watts Alexander, Auburn University
Dr. Mark Bolding, UAB
Dr. Sara Cooper, HudsonAlpha Institute for Biotechnology
Dr. Andrew Frugé, Auburn University
Dr. Yulia Khodneva, UAB
Dr. Haiyan Qu, UAB
Dr. Nan Cher Yeo, UAB
2020
Dr. Yu Gan, University of Alabama
Dr. Austin Robinson, Auburn University
Dr. Sixto Leal, UAB
Dr. Josh Stern, UAB
Dr. Brittany Lasseigne, UAB
Dr. Barbara Gower, UAB
Dr. Balasubramanyam Karanam, Tuskegee University
2019
Dr. Erin Ahn, University of South Alabama
Dr. Pankaj Arora, UAB
Dr. Ninh Doan, University of South Alabama
Dr. Michael Greene, Auburn University
Dr. Orlando Gutierrez, UAB
Dr. Elizabeth Lipke, University of South Alabama
Dr. Arun Paul, UAB
Dr. Mike Wells, UAB
Dr. Huifeng Yun, UAB
2018
Silas Leavesley, University of South Alabama
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2016
Markus Bredel, MD, PhD (UAB Radiation Oncology)
Inhibiting PTBP1 to Reduce EGFR Signaling in Glioblastoma
Javier Campos-Gomez, PhD (Southern Research)
High Throughput Screening of Small Molecules Targeting Oxylipins Production by Pseudomonas aeruginosa as Novel Candidates for Anti-Virulence Therapy
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2015
Rajeev Samant (UAB Oncology)
Development of a high throughput screen for inhibitors of EMT
Hao Jiang and Will Placzek (UAB Oncology)
Developing small-molecule inhibitors of an epigenetic regulator for MYC-dependent malignancies
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2014
Bo Xu (Southern Research)
Inhibitors of ATM-NBS1 interaction for cancer radiosensitization
Kim Keeling and David Bedwell (UAB)
Identification of Compounds that Mediate PTC Suppression
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2013
Mary-Ann Bjornsti, PhD
The SUMO conjugation pathway as a therapeutic target for Myc-driven tumors
Michael Niederweis, PhD
Targeting siderophore secretion, an Achilles heel of Mycobacterium tuberculosis
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2012
Frances E. Lund, PhD
Treating B cell-derived neoplasms by targeting the ectoenzyme CD38: a regulator of the NAD metabolic pathway
Sunnie R. Thompson, PhD
Development of an anticancer therapeutic against ribosomoal protein S25
Anupam Agarwal, MD
Screening for novel modulators of heme oxygenase-1 expression in human disease
Anath Shalev, MD
TXNIP Inhibitors: A novel approach to diabetes therapy
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2011
Xu Feng, PhD (UAB, Department of Molecular & Cellular Pathology)
Identification of Anti-RANK Signaling Compounds via HTS of Cell-Based Assays for Preventing and Treating Cancer Bone Metastases
David Schneider, PhD (UAB, Department of Biochemistry and Molecular Genetics)
Developing a fully-reconstituted human RNA Polymerase I transcription assay for drug screening
Corinne Griguer, PhD (UAB, Department of Surgery)
Cytochrome c oxidase inhibitors: Novel therapeutic approach to prevent / reverse cancer chemoresistance
*Louise Hecker, PhD (UAB, Department of Medicine)
Identification of Small Molecule Inhibitors Targeting NOX4
Joanne Murphy-Ullrich, PhD (UAB, Department of Molecular & Cellular Pathology)
Development of small molecule antagonists for blockade of TSP1-dependent TGFbeta activation for treatment of multiple myeloma
Erik Roberson, MD, PhD (UAB, Department of Neurology)
Targeting the Tau–Fyn Interaction in Alzheimer’s Disease
*William Parker, PhD (Southern Research) and Jaideep Thottassery, PhD (Southern Research)
Novel DNA Demethylating Nucleosides: T-dCyd, 5F- T-dCyd and 5-Aza-T-dCyd
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2010
Stephen Aller, PhD (UAB, Department of Pharmacology & Toxicology)
In silico screening and structure-based drug design for inhibitors of a multi-drug resistance transporter
*John Chatham, PhD (UAB, Department of Medicine) and Richard Marchase, PhD (UAB, Department of Cell Biology)
Prevention of stress-induced cellular calcium overload by inhibition of STIM1 mediated calcium entry pathways: A new therapy for ischemic injury
*Olaf Kutsch, PhD (UAB, Department of Medicine)
Hit & run stimulation to reactivate latent HIV-1 infection
Robert van Waardenburg, PhD (UAB, Department of Pharmacology & Toxicology)
Identification of small molecule poisons of the DNA repair protein Tyrosyl-DNA Phosphodiesterase I (TDP1)
Talene Yacoubian, MD, PhD (UAB, Department of Neurology)
Screening for inducers of 14-3-3theta expression for treatment of Parkinson’s Disease
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2009
*W. Timothy Garvey, MD (UAB, Department of Nutrition Sciences) and Yuchang Fu, PhD (UAB, Department of Nutrition Sciences)
NR4A3 Orphan Nuclear Receptor as a Target for the Treatment of Insulin Resistance
*Krister Wennerberg, PhD (Southern Research Institute)
Discovery and Development of Ect2 Inhibitors as Anti-Cancer Drugs
*Andrew West, PhD (UAB, Department of Neurology)
Discovery of LRRK2 kinase inhibitors for treatment of Parkinson’s Disease
Sadanandan Velu, PhD (UAB, Department of Chemistry)
Novel Marine Alkaloid Analogs for Breast Cancer Therapy
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2008
Scott Blume, PhD (UAB, Department of Medicine; Division of Hematology & Oncology)
A Strategy to Specifically Modulate the Translation of Individual Cancer-Relevant Genes
Lawrence J. DeLucas, OD, PhD (UAB, Department of Optometry)
USP2a, a Deubiquitinating Protein Implicated in Prostate Cancer
*L. Burt Nabors, MD (UAB, Department of Neurology)
The Post-transcriptional Regulator, HuR, as a Novel Therapeutic Target in Malignant Glioma
Advanced Scientific Review of Clinical Research
Studies involving human subjects play a vital role in the translation of scientific discovery to impact health. To be successful, these projects rely on rigorous and scientifically valid study design, detailed analytic plans and operational feasibility. Formal Scientific Review Committees (SRCs) play a critical role in this process by partnering with investigators to assess methodologic rigor, study feasibility and data management plans. These committees also offer a level of protocol pre-review to harmonize documentation and to potentially reduce the time to IRB approval.Click below to access the Scientific Review Committee pertinent to your clinical research initiative:
| Department of Medicine Scientific Review Committee (SRC) The DOM SRC reviews all non-cancer-related projects within the Department of Medicine. |
Comprehensive Cancer Center Clinical Trials Review Committee (CTRC) The CTRC reviews all cancer-related projects at UAB. |
ADDITIONAL RESOURCES
| Study Enrollment Feasibility |
Training GCP Training IRB Training |
Sharpen Your Science CCTS Project Panels CCTS Biostatistics, Epidemiology and Research Design |