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Project NameNCTSitesSample SizeDesignStart YearEnd YearFunding Agency
Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children (ARRC Trial) NCT05026749 7 370 Parallel RCT 2021 2026 NICHD
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial – Hemodynamics (CREST-H) NCT03121209 56 385 Phase 3 Parallel RCT 2017 2027 NINDS
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) NCT02089217 168 2480 Parallel RCT 2014 2026 NINDS
Childhood Follow-Up Study of Obesity and Neurodevelopment After Perinatal Exposure to Adjunctive Azithromycin Prophylaxis for Cesarean Delivery (C/SOAP Neuro Follow-Up Study)   14 1410 Follow-Up Cohort 2020 2025 NICHD
Childhood Pulmonary and Related Outcomes after Perinatal Exposure to Adjunctive Azithromycin Prophylaxis for Cesarean Delivery (C/SOAP Pulmonary Follow-up Study)   14 1410 Follow-Up Cohort 2020 2024 NICHD
Coordinated, Collaborative, Comprehensive, Family-based, Integrated and Technology-enabled Care (C3FIT) NCT04000971 22 1,200 Cluster Randomized 2020 2025 PCORI
CREST-2 Long-term Observational Extension Study (C2LOE) NCT05465122 51 2480 Longitudinal Cohort 2022 2026 NINDS
HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors NCT02457845 2 13 Phase I Trial 2020 2024 FDA
Offspring Neurodevelopment and Growth after Early-Pregnancy Antihypertensive Therapy OR Preeclampsia in Women with Chronic Hypertension (CHAP Child Follow-up Study)   61 1470 Follow-Up Cohort 2024 2028 NHLBI
Optimization of Saturation Targets And Resuscitation Trial (OptiSTART) NCT05849077 10 700 Parallel RCT 2024 2027 NICHD
Pregnancy as a Window to the Future: Outcomes of Antihypertensive Therapy and Superimposed Preeclampsia in Pregnant Women with Mild Chronic Hypertension (CHAP Maternal Follow-up Study)   61 1470 Follow-Up Cohort 2021 2026 NHLBI
Pregnancy, Postpartum, and Postnatal Health Enhancing Quality and Access to achieve Equitable Maternal and Infant Health (P3EUATE)   5   Network: Methods, Data Analysis, and Implementation Core 2022 2026 American Heart Association
Premature Infants Receiving Cord Milking or Delayed Cord Clamping (PREMOD2) NCT03019367 19 1201 Parallel RCT, Follow-Up Cohort 2019 2025 NIH
Providing an Optimized and Empowered Pregnancy for You (P3OPPY)  NCT06510075 1 400 2x2 Factorial RCT 2024 2027 American Heart Association
REasons for Geographic and Racial Differences in Stroke (REGARDS)     30,239 Longitudinal Cohort 2003 2026 NINDS
RESTORE (AddREssing Social Determinants TO pRevent hypErtension) Network   5   Network: Statistical Core 2021 2025 American Heart Association
Risk Underlying Rural Areas Longitudinal Cohort Study (RURAL) Heart and Lung Study NCT05006729 10 4600 Longitudinal Cohort 2021 2025 NHLBI
Study of Pembrolizumab and M032 (NSC 733972) NCT05084430 1 28 Phase I/II Trial 2022 2027 NCI
Trial of C134 in Patients With Recurrent GBM (C134-HSV-1) NCT03657576 1 19 Phase I Trial 2019 2026 Gateway for Cancer Research
Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease (Tele-COPD) NCT05119556 14 768 Phase 3 Parallel RCT 2022 2027 NHLBI

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