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Antiviral Drug Discovery and Development Center Heersink School of Medicine

Publications

Publications resulting from the work within AD3C:

  • Year 2020
    • Xu J, Shi PY, Li H, Zhou J. Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential. ACS Infect Dis. 2020 May 8;6(5):909-915. doi: 10.1021/acsinfecdis.0c00052. Epub 2020 Mar 10. PMID: 32125140; PMCID: PMC7098069.
    • Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 Apr 29;12(541):eabb5883. doi:10.1126/scitranslmed.abb5883. Epub 2020 Apr 6. PMID: 32253226; PMCID: PMC7199910.
    • Noll KE, Whitmore AC, West A, McCarthy MK, Morrison CR, Plante KS, Hampton BK, Kollmus H, Pilzner C, Leist SR, Gralinski LE, Menachery VD, Schäfer A, Miller D, Shaw G, Mooney M, McWeeney S, Pardo-Manuel de Villena F, Schughart K, Morrison TE, Baric RS, Ferris MT, Heise MT. Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross. Cell Rep. 2020 Apr 28;31(4):107587. doi: 10.1016/j.celrep.2020.107587. PubMed PMID: 32348764; PubMed Central PMCID: PMC7195006.
    • Xie X, Muruato A, Lokugamage KG, Narayanan K, Zhang X, Zou J, Liu J, Schindewolf C, Bopp NE, Aguilar PV, Plante KS, Weaver SC, Makino S, LeDuc JW, Menachery VD, Shi PY. An Infectious cDNA Clone of SARS-CoV-2. Cell Host Microbe. 2020 Apr 9:S1931-3128(20)30231-6. doi: 10.1016/j.chom.2020.04.004. Epub ahead of print. PMID: 32289263; PMCID: PMC7153529.
    • Murphy Schafer AR, Smith JL, Pryke KM, DeFilippis VR, Hirsch AJ. The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection. Front Microbiol. 2020 Feb 14;11:24. doi: 10.3389/fmicb.2020.00024. eCollection 2020. PubMed PMID: 32117091; PubMed Central PMCID: PMC7033647.
    • McCarthy MK, Reynoso GV, Winkler ES, Mack M, Diamond MS, Hickman HD, Morrison TE. MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2. PLoS Pathog. 2020 Jan 30;16(1):e1008292. doi: 10.1371/journal.ppat.1008292. eCollection 2020 Jan. PubMed PMID: 31999809; PubMed Central PMCID: PMC7012455.
    • Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, Cihlar T, Jordan R, Denison MR, Baric RS. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020 Jan 10;11(1):222. doi: 10.1038/s41467-019-13940-6. PubMed PMID: 31924756; PubMed Central PMCID: PMC6954302.
  • Year 2019
    • Li G, Adam A, Luo H, Shan C, Cao Z, Fontes-Garfias CR, Sarathy VV, Teleki C, Winkelmann ER, Liang Y, Sun J, Bourne N, Barrett ADT, Shi PY, Wang T. An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses. NPJ Vaccines. 2019 Nov 28;4:48. doi: 10.1038/s41541-019-0143-3. PMID: 31815005; PMCID: PMC6883050.
    • Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, Denison MR. Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance. J Virol. 2019 Nov 26;93(24):e01348-19. doi: 10.1128/JVI.01348-19. PMID: 31578288; PMCID: PMC6880162.
    • Broeckel RM, Haese N, Ando T, Dmitriev I, Kreklywich CN, Powers J, Denton M, Smith P, Morrison TE, Heise M, DeFilippis V, Messaoudi I, Curiel DT, Streblow DN. Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease. Front Immunol. 2019 Oct 31;10:2563. doi: 10.3389/fimmu.2019.02563. PMID: 31736977; PMCID: PMC6834551.
    • Zhang X, Xie X, Xia H, Zou J, Huang L, Popov VL, Chen X, Shi PY. Zika Virus NS2A-Mediated Virion Assembly. mBio. 2019 Oct 29;10(5):e02375-19. doi: 10.1128/mBio.02375-19. PMID: 31662457; PMCID: PMC6819661.
    • Zhang X, Xie X, Zou J, Xia H, Shan C, Chen X, Shi PY. Genetic and biochemical characterizations of Zika virus NS2A protein. Emerg Microbes Infect. 2019;8(1):585-602. doi: 10.1080/22221751.2019.1598291. PMID: 30958095; PMCID: PMC6455252.
    • Lim XN, Shan C, Marzinek JK, Dong H, Ng TS, Ooi JSG, Fibriansah G, Wang J, Verma CS, Bond PJ, Shi PY, Lok SM. Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C. PLoS Pathog. 2019 Sep 19;15(9):e1007996. doi: 10.1371/journal.ppat.1007996. PMID: 31536610; PMCID: PMC6752767.
    • Brown AJ, Won JJ, Graham RL, Dinnon KH 3rd, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP. Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase. Antiviral Res. 2019 Sep;169:104541. doi: 10.1016/j.antiviral.2019.104541. Epub 2019 Jun 21. PubMed PMID: 31233808; PubMed Central PMCID: PMC6699884.
    • Leist SR, Jensen KL, Baric RS, Sheahan TP. Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis. PLoS One. 2019 Jul 24;14(7):e0220126. doi: 10.1371/journal.pone.0220126. eCollection 2019. PubMed PMID: 31339932; PubMed Central PMCID: PMC6655769.
    • Pruijssers AJ, Denison MR. Nucleoside analogues for the treatment of coronavirus infections. Curr Opin Virol. 2019 Apr;35:57-62. doi: 10.1016/j.coviro.2019.04.002. Epub 2019 May 21. Review. PubMed PMID: 31125806; PubMed Central PMCID: PMC7102703.
    • Broeckel R, Sarkar S, May NA, Totonchy J, Kreklywich CN, Smith P, Graves L, DeFilippis VR, Heise MT, Morrison TE, Moorman N, Streblow DN. Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs. Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02325-18. doi: 10.1128/AAC.02325-18. Print 2019 Apr. PubMed PMID: 30917980; PubMed Central PMCID: PMC6496153.
    • Amaral JK, Taylor PC, Teixeira MM, Morrison TET, Schoen RT. The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis. Viruses. 2019 Mar 22;11(3):289. doi: 10.3390/v11030289. PMID: 30909365; PMCID: PMC6466451.
  • Year 2018
    • Smith JL, Sheridan K, Parkins CJ, Frueh L, Jemison AL, Strode K, Dow G, Nilsen A, Hirsch AJ. Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions. Antiviral Res. 2018 Jul;155:12-19. doi: 10.1016/j.antiviral.2018.04.019. Epub 2018 Apr 27. PubMed PMID: 29709563.
    • McCarthy MK, Davenport BJ, Reynoso GV, Lucas ED, May NA, Elmore SA, Tamburini BA, Hickman HD, Morrison TE. Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment. JCI Insight. 2018 Jul 12;3(13). pii: 121100. doi: 10.1172/jci.insight.121100. PubMed PMID: 29997290; PubMed Central PMCID: PMC6124534.
    • Shin JS, Jung E, Kim M, Baric RS, Go YY. Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro. Viruses. 2018 May 24;10(6). pii: E283. doi: 10.3390/v10060283. PubMed PMID: 29795047; PubMed Central PMCID: PMC6024778.
    • Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8. PubMed PMID: 29525521; PubMed Central PMCID: PMC6251713.
    • Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. mBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18. PubMed PMID: 29511076; PubMed Central PMCID: PMC5844999.
    • Carpentier KS, Morrison TE. Innate immune control of alphavirus infection. Curr Opin Virol. 2018 Feb;28:53-60. doi: 10.1016/j.coviro.2017.11.006. Epub 2017 Nov 22. Review. PubMed PMID: 29175515; PubMed Central PMCID: PMC5835171.
  • Year 2017
    • Jones JE, Long KM, Whitmore AC, Sanders W, Thurlow LR, Brown JA, Morrison CR, Vincent H, Peck KM, Browning C, Moorman N, Lim JK, Heise MT. Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology. mBio. 2017 Nov 14;8(6). pii: e01456-17. doi: 10.1128/mBio.01456-17. PubMed PMID: 29138302; PubMed Central PMCID: PMC5686535.
    • Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653. PubMed PMID: 28659436; PubMed Central PMCID: PMC5567817.
    • Pryke KM, Abraham J, Sali TM, Gall BJ, Archer I, Liu A, Bambina S, Baird J, Gough M, Chakhtoura M, Haddad EK, Kirby IT, Nilsen A, Streblow DN, Hirsch AJ, Smith JL, DeFilippis VR. A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. mBio. 2017 May 2;8(3). pii: e00452-17. doi: 10.1128/mBio.00452-17. PubMed PMID: 28465426; PubMed Central PMCID: PMC5414005.
    • McCarthy MK, Morrison TE. Persistent RNA virus infections: do PAMPS drive chronic disease? Curr Opin Virol. 2017 Apr;23:8-15. doi: 10.1016/j.coviro.2017.01.003. Epub 2017 Feb 17. Review. PubMed PMID: 28214732; PubMed Central PMCID: PMC5474173.
  • Year 2016
    • Haese NN, Broeckel RM, Hawman DW, Heise MT, Morrison TE, Streblow DN. Animal Models of Chikungunya Virus Infection and Disease. J Infect Dis. 2016 Dec 15;214(suppl 5):S482-S487. Review. PubMed PMID: 27920178; PubMed Central PMCID: PMC5137241.
    • Mounce BC, Cesaro T, Moratorio G, Hooikaas PJ, Yakovleva A, Werneke SW, Smith EC, Poirier EZ, Simon-Loriere E, Prot M, Tamietti C, Vitry S, Volle R, Khou C, Frenkiel MP, Sakuntabhai A, Delpeyroux F, Pardigon N, Flamand M, Barba-Spaeth G, Lafon M, Denison MR, Albert ML, Vignuzzi M. Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses. J Virol. 2016 Oct 14;90(21):9683-9692. doi: 10.1128/JVI.01347-16. Print 2016 Nov 1. PubMed PMID: 27535047; PubMed Central PMCID: PMC5068521.
    • Morrison CR, Plante KS, Heise MT. Chikungunya Virus: Current Perspectives on a Reemerging Virus. Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.EI10-0017-2016. Review. PubMed PMID: 27337473; PubMed Central PMCID: PMC6488301.
    • Everts M, Suto MJ, Painter GR, Whitley RJ. Consortia's critical role in developing medical countermeasures for re-emerging viral infections: a USA perspective. Future Virol. 2016 Mar;11(3):187-195. Epub 2016 Feb 29. PubMed PMID: 27325914; PubMed Central PMCID: PMC4912138.
    • McCarthy MK, Morrison TE. Chronic chikungunya virus musculoskeletal disease: what are the underlying mechanisms? Future Microbiol. 2016;11(3):331-4. doi: 10.2217/fmb.15.147. Epub 2016 Mar 4. PubMed PMID: 26939523; PubMed Central PMCID: PMC4842256.
    • Rasmussen L, White EL, Bostwick JR. Acoustic Droplet Ejection Applications for High-Throughput Screening of Infectious Agents. J Lab Autom. 2016 Feb;21(1):188-97. doi: 10.1177/2211068215620345. Epub 2015 Dec 9. PubMed PMID: 26663786.
  • Year 2015
    • Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed PMID: 26646986; PubMed Central PMCID: PMC4672893.
    • Long KM, Ferris MT, Whitmore AC, Montgomery SA, Thurlow LR, McGee CE, Rodriguez CA, Lim JK, Heise MT. γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease. J Virol. 2015 Oct 21;90(1):433-43. doi: 10.1128/JVI.02159-15. Print 2016 Jan 1. PubMed PMID: 26491151; PubMed Central PMCID: PMC4702549.
    • Broeckel R, Haese N, Messaoudi I, Streblow DN. Nonhuman Primate Models of Chikungunya Virus Infection and Disease (CHIKV NHP Model). Pathogens. 2015 Sep 16;4(3):662-81. doi: 10.3390/pathogens4030662. Review. PubMed PMID: 26389957; PubMed Central PMCID: PMC4584280.
    • Long KM, Heise MT. Protective and Pathogenic Responses to Chikungunya Virus Infection. Curr Trop Med Rep. 2015 Mar;2(1):13-21. PubMed PMID: 26366337; PubMed Central PMCID: PMC4564112.
    • Mainou BA, Ashbrook AW, Smith EC, Dorset DC, Denison MR, Dermody TS. Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry. J Virol. 2015 Sep;89(17):8701-12. doi: 10.1128/JVI.00739-15. Epub 2015 Jun 24. PubMed PMID: 26109733; PubMed Central PMCID: PMC4524060.
    • Chiang C, Beljanski V, Yin K, Olagnier D, Ben Yebdri F, Steel C, Goulet ML, DeFilippis VR, Streblow DN, Haddad EK, Trautmann L, Ross T, Lin R, Hiscott J. Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists. J Virol. 2015 Aug;89(15):8011-25. doi: 10.1128/JVI.00845-15. Epub 2015 May 27. PubMed PMID: 26018150; PubMed Central PMCID: PMC4505665.
  • Year 2014
    • Smith EC, Sexton NR, Denison MR. Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses. Annu Rev Virol. 2014 Nov;1(1):111-32. doi: 10.1146/annurev-virology-031413-085507. Epub 2014 Jun 2. PubMed PMID: 26958717.
    • Burrack KS, Morrison TE. The role of myeloid cell activation and arginine metabolism in the pathogenesis of virus-induced diseases. Front Immunol. 2014 Sep 8;5:428. doi: 10.3389/fimmu.2014.00428. eCollection 2014. Review. PubMed PMID: 25250029; PubMed Central PMCID: PMC4157561.
    • Morrison TE. Reemergence of chikungunya virus. J Virol. 2014 Oct;88(20):11644-7. doi: 10.1128/JVI.01432-14. Epub 2014 Jul 30. Review. PubMed PMID: 25078691; PubMed Central PMCID: PMC4178719.
    • Menachery VD, Yount BL Jr, Josset L, Gralinski LE, Scobey T, Agnihothram S, Katze MG, Baric RS. Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity. J Virol. 2014 Apr;88(8):4251-64. doi: 10.1128/JVI.03571-13. Epub 2014 Jan 29. PubMed PMID: 24478444; PubMed Central PMCID: PMC3993736.