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Canine Immunoneurotherapeutics Trial Heersink School of Medicine

Canine Immunoneurotherapeutics Trial

Canine Immunoneurotherapeutics Trial

People share many things with the dogs in their lives. Unfortunately, that can include a tendency to develop brain tumors.

We share more than our lives with our pets – we share our living space, our air, our recreational activities and sometimes our food. One Medicine is the concept that veterinary in human medicines often overlap and that each can learn from the other to the benefit of both.

Our Canine Immunoneurotherapeutics Trial, or CANINE, has received funding from the National Institutes of Health to use human therapies to treat and study canine brain tumors. Interestingly, dogs and humans develop malignant brain tumors at about the same rate, and these tumors are biologically similar. A trial like this allows us to provide compassionate care to animals, advance the field of veterinary medicine and better understand the biological effects of treatment. Discovering what we have in common may just lead to a cure.

Please review the information on this site to determine if our trial is right for you and your pet. Veterinarians may contact any of the regional study sites for more information regarding referrals.

Dogs and humans develop malignant brain tumors at about the same rate and with similar biology.

Dogs and humans develop malignant brain tumors at about the same rate and with similar biology.

Learn more

The current phase of this trial will establish the maximum safe and effective dose of M032, the FDA-approved, clinical-grade oncolytic herpes simplex virus that expresses an IL-12.

The current phase of this trial will establish the maximum safe and effective dose of M032, the FDA-approved, clinical-grade oncolytic herpes simplex virus that expresses an IL-12.

Learn more

Research reported in this webpage is supported by the National Cancer Institute of the National Institutes of Health under Award Number U01CA224151. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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  • SELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid` FROM `evjwE_modules` AS `m` LEFT JOIN `evjwE_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id` LEFT JOIN `evjwE_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id` WHERE ( ( (`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1)) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND (`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) ORDER BY `m`.`position`,`m`.`ordering`18.21ms2.94KBParams/libraries/src/Cache/Controller/CallbackController.php:51Copy
  • SELECT `params` FROM `evjwE_tagz` WHERE `component_id` = 174 AND `component_type` = "menu"29.11ms840B/plugins/system/tagz/tagz.php:673Copy
  • SELECT `params` FROM `evjwE_tagz` WHERE `component_id` = 2 AND `component_type` = "content"829μs840B/plugins/system/tagz/tagz.php:673Copy
  • SELECT `name`,`element` FROM `evjwE_extensions` WHERE `type` = 'plugin' AND `folder` = 'finder' AND `enabled` = 151.27ms1.16KB/administrator/components/com_finder/src/Helper/LanguageHelper.php:135Copy
  • SELECT `title` FROM `evjwE_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1)30.13ms968B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `evjwE_scheduler_tasks` AS `a` WHERE `a`.`state` = 110.97ms1.71KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:517Copy
  • SELECT `session_id` FROM `evjwE_session` WHERE `session_id` = ?10.51ms1.64KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291Copy
  • UPDATE `evjwE_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?16.28ms912BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy