The Center for Injury Science, founded in 1999, conducts research to promote injury prevention and to improve trauma care. Our mission is to improve outcomes from injury at all stages of care, from the prehospital setting through to resuscitation, acute care and rehabilitation.
Our approach is cross-cutting and multidisciplinary. We support research across UAB and have experience working with the following departments:
|
|
|
|
|
|
The center is comprised of four research units: the Clinical Trials Unit, the Trauma Care Delivery Research Unit and the Basic Science and Translational Research Unit.
Complete Project Listing:
| Study Title | PI | Short Description | Status | Clinical Trials.gov Link |
| Trauma Resuscitation with Group O Whole Blood Or Products | Jansen / Hurst | A multicenter clinical trial (TROOP) comparing whole blood vs conventional separated component blood in the resuscitation of traumatic hemorrhagic shock. | Enrolling | |
| Non-Invasive Monitoring of Traumatic Brain Injury Progression using the Infrascanner | Black | To evaluate the feasibility of hourly Infrascanner use in TBI patients and the devices ability to detect enlargement of intracranial hematomas and avoiding routine repeat CT scans in patients with mild or moderately severe traumatic brain injuries. | Enrolling | https://clinicaltrials.gov/study/NCT04893837 |
| Evaluation of BE1116 (4F-PCC) in patients with traumatic injury and confirmed or suspected acute major bleeding to improve survival | Jansen / Cox | This is a prospective, multicenter, randomized, double-blind, placebo controlled, parallel-group, large simple trial to investigate the efficacy and safety of a single intravenous (IV) infusion of BE1116 in patients with traumatic injury and confirmed or suspected acute major bleeding predicted to receive a large volume blood product transfusion. | Enrolling | https://clinicaltrials.gov/study/NCT05568888 |
| Plasma Resuscitation withOut Lung Injury | Jansen | An open-label, phase IV, multicenter, randomized controlled prospective clinical trial to 1) determine whether the administration of Pathogen-Reduced Plasma during burn resuscitation results in decreased total resuscitation volumes compared to standard-of-care crystalloid-based resuscitation, 2) determine whether Pathogen-Reduced Plasma administration during burn resuscitation reduces ARDS, 3) determine the effect of Pathogen-Reduced Plasma administration on the endotheliopathy of burns. | Enrolling | https://clinicaltrials.gov/study/NCT04681638 |
| A Randomized Clinical Trial of Scenario Planning for Older Adults with Serious Injury | Gelbard | The objective of this proposal is to test the effectiveness of the Best Case/Worst Case-ICU communication tool on quality of communication, clinician moral distress, and ICU length of stay for older adults with severe traumatic injury. | Enrolling | https://clinicaltrials.gov/study/NCT05780918 |
| DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS) | Davies | The purpose of this study is to compare Cryopreserved Platelets to standard of care Liquid Stored Platelets in controlling blood loss in patients undergoing Cardiopulmonary Bypass Surgery. | Start-up | https://clinicaltrials.gov/study/NCT04709705 |
| WounDx Clinical Decision Support Tool | Gelbard | To evaluate the use of inflammatory biomarker expression and clinical data in a clinical decision support tool to estimate the timing for delayed closure of traumatic extremity wounds. | Start-up | |
| Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial | Hashmi | A multicenter clinical trial designed to compare the administration of whole blood to standard practice in a prehospital setting for the resuscitation of patients at risk for shock due to trauma-related hemorrhage. This study will also evaluate patient outcomes based upon the age of whole blood administered. | Start-up | https://clinicaltrials.gov/study/NCT04684719 |
| FFP In Traumatic BRAin INjury (FIT-BRAIN) Tri | Jansen | To perform a Phase 2/3, Randomized, Multicenter Study to Evaluate the Efficacy of Fresh Frozen Plasma in Subjects with Moderate to Severe Traumatic Brain Injury. | Start-up | https://clinicaltrials.gov/study/NCT06062888 |
| Strategy to Avoid Excessive Oxygen for Critically Ill Burn Patients | Hwang | To determine the feasibility, safety, and effectiveness of the targeted normoxia approach to conserve oxygen and improve clinical outcomes in critically injured patients. | Close-out | https://clinicaltrials.gov/study/NCT04534972 |
| Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients | Jansen | To determine the feasibility, safety, and effectiveness of the targeted normoxia approach to conserve oxygen and improve clinical outcomes in critically injured patients. | Close-out | https://clinicaltrials.gov/study/NCT04534959 |