Studying whether taking a commonly used heart medication can prevent dementia.
The largest randomized trial ever conducted exclusively in older adults, PREVENTABLE tests the effectiveness of statins for the prevention of new dementia or persisting disability. The study will fill a key evidence gap regarding:
- The usefulness of statins for prolonging healthy life years and primary cardiovascular prevention in adults over age 75, especially in the setting of multiple chronic conditions.
- The usefulness of statins to address other common conditions such as mild cognitive impairment/dementia, physical disability, or heart failure with preserved ejection fraction (HFpEF) may be improved by an effective vascular prevention.
Pragmatic studies like PREVENTABLE are particularly ideal for older adults.
PREVENTABLE will follow up to 20,000 study participants by reviewing their health records and through a phone call or a home visit. Researchers will also mail study drug directly to a participant's home.