iSB members use structural, biochemical, and biophysical methodologies to study problems related to bacterial and viral infections, immunity, cancer, and cell signaling, focusing on understanding and treating various diseases, and developing new drugs:

Structural Virology

• Cingolani Lab: nuclear import of viruses; bacteriophages structure and function
• Dokland Lab: virus assembly and bacterial pathogenicity
• Green Lab: structure-function relationships of viral replication, capsid structure
• Petit Lab: influenza non-structural protein 1 (NS1)
• Prevelige Lab: structural mass spectrometry of HIV1
• Saad Lab: membrane-protein and protein-protein interactions critical for HIV assembly

Bacterial Pathogens

• Aller Lab: structure and function of LDL visualized by cryo-EM
• Calix Lab: bacterial pathogens; Infectious Diseases; microbial surface glycans
• Chattopadhyay Lab: structural biology of enzyme pathways from pathogenic parasites
• Cingolani Lab: Pseudomonas-phages structure and genome-ejection mechanisms
• Deivanayagam Lab: antimicrobials against gram-positive bacterial surface proteins
• Kharlampieva Lab: design and synthesis of polymeric materials for controlled delivery of drugs
• Niederweis Lab: Functions and structures of outer membrane proteins of Mycobacterium tuberculosis
• Ulijasz Lab: Mechanisms of bacterial pathogenicity 
• Wang (Jerry) Lab: structural biology and engineering of microbial pili
• Wang (Pengfei) Lab: Saponin-based semisynthetic vaccine adjuvants

Molecular Immunity

• Kharlampieva Lab: design and synthesis of polymeric materials for controlled delivery of drugs
• Novak Lab: structure and function of autoantibodies specific for aberrant glycoproteins found in human diseases
• Renfrow Lab: O-glycans found on the immunoglobulin IgA1 as related to the pathogenesis of IgA nephropathy
• Walter Lab: structure-function studies on host and viral proteins that alter the immune system
• Wang (Pengfei) Lab: Mechanism and structure-activity relationship studies of saponin immunostimulants

Cancer and Cell Signaling

• Bedwell Lab: translation termination in eukaryotes
• Cingolani Lab: trafficking of signaling molecules into the cell nucleus
• Kharlampieva Lab: design and synthesis of polymeric materials for controlled delivery of drugs
• Marsiglia Lab: signal Transduction, PI3K-AKT signaling and chemcial biology
• Placzek Lab: anti-cancer target validation and structure-based drug discovery using NMR
• Saad Lab: membrane-protein and protein-protein interactions critical for HIV assembly
• Song Lab: identification of small molecule drug candidates to regulate important cellular activities in cancer
• Walter Lab: structure-function studies on host and cytokines and signaling molecules
• Velu Lab: medicinal chemistry and drug discovery
• Wang (Jerry) Lab: self-assembling nanotubes for drug delivery
• Wang (Pengfei) Lab: synthetic cancer vaccines
• Zhang Lab: intrinsically disordered protein, RNA-binding proteins and RNA splicing