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Division of Nephrology Heersink School of Medicine

Research Opportunities

 Research Interests

BASIC SCIENCE

{slide=Acute Kidney Injury (AKI), Tubular pathophysiology}

  • Anupam Agarwal, M.D.
  • Daniel F. Balkovetz, M.D., Ph.D.
  • Lisa M. Curtis, PhD
    1. Cellular sources of epithelial repair in AKI
    2. Sex differences in heme oxygenase-1 (HO-1) in the kidney
    3. Pathobiology of AKI in the aging kidney.
  • Timothy Garvey, M.D.
  • Roslyn Mannon, M.D.
  • Michal Mrug, M.D.
  • Paul Sanders, MD
    1. Monoclonal immunoglobulin light chain-related renal diseases, including acute kidney injury, cast nephropathy, monoclonal light chain-related glomerulopathy and amyloidosis, type AL
    2. Hypertensive nephrosclerosis
  • Bradley Yoder, Ph.D.
    {/slide}

{slide=Renal Transport Physiology}

  • Daniel F. Balkovetz, M.D., Ph.D.
  • Mark Bevensee, PhD
    1. Cellular and Molecular Physiology of Intracellular pH regulation and acid-base transporters
  • Ji Bin Peng, Ph.D.
  • David Pollock, PhD
    1. Endothelin regulation of sodium homeostasis and salt-sensitive hypertension
    2. Circadian control of blood pressure
    3. Pathogenesis of sickle cell Nephropathy
  • Jennifer Pollock, PhD
    1. Endothelin and Nitric Oxide regulation of sodium excretion and salt-sensitive hypertension
    2. Early life stress, vascular disease, and hypertension
    3. Renal tubular function and diabetic nephropathy
  • M. Tino Unlap, PhD, CRA
    1. Genetic basis of hypertension 
    2. The role of the Na+/Ca2+ exchanger in hypertension 
    3. The link between oxidative stress and endogenous ouabain in hypertension

{/slide}

{slide=Glomerular Disease}

  • Bruce Julian, MD
    1. Pathogenesis of IgA Nephropathy
    2. Familial IgA Nephropathy
  • Caroline Marshall, MD
  • Jan Novak, M.D.
    {/slide}

{slide=Vascular Biology and Nitric Oxide}

  • Anupam Agarwal, M.D.
  • Edward Inscho, PhD
    1. The control of the renal microcirculation
    2. Autoregulatory impairment in hypertension
    3. Impact of High Dietary salt on afferent arteriole function
  • Timmy Lee, MD
    1. Pathophysiologic MEchanisms of Ateroiovenous Fistula Stenosis and Neointimal Hyperplasia Development
    2. Pathophysiologic Mechanisms of Balloon Angioplasty Injury in Ateriovenous Fistulas
    3. Novel Therapies to Inhibit Neointimal Hyperplasia Development in Vascular Access
  • Jennifer Pollock, PhD
    1. Endothelin and Nitric Oxide Regulation of sodium excretion and salt-sensitive hypertension
    2. Epigenetic and post-transplational modifications of Nitric Oxide Synthase
    3. Nitric Oxide Synthase and Vascular Function
  • Paul Sanders, MD
    1. Monoclonal immunoglobulin light chain-related renal diseases, including acute kidney injury, cast nephropathy, monoclonal light chain-related glomerulopathy and amyloidosis, type AL
    2. Hypertensive nephrosclerosis
  • Alexander Szalai, Ph.D.
  • Roger White, Ph.D.
    {/slide}

{slide=Matrix Biology}

  • Daniel F. Balkovetz, M.D.
  • Jannett Katz, Ph.D.
  • Roslyn Mannon, M.D.
  • Joanne Murphy-Ullrich, Ph.D.
    {/slide}

{slide=Transplantation}

  • Roslyn Mannon, M.D.

{/slide}
{slide=Genetics}

  • Daniel C. Bullard, Ph.D.
  • Michal Mrug, M.D.
  • M. Tino Unlap, PhD, CRA
    1. Genetic basis of hypertension 
    2. The role of the Na+/Ca2+ exchanger in hypertension 
    3. The link between oxidative stress and endogenous ouabain in hypertension
  • Bradley Yoder, Ph.D.

{/slide}
{slide=Immunology}

  • Anupam Agarwal, M.D.
  • James George, Ph.D.
  • Roslyn Mannon, M.D.
  • Jiri Mestecky, M.D.
  • Michal Mrug, M.D.
  • Jan Novak, Ph.D.
  • Alexander Szalai, PhD
    {/slide}

{slide=Stem Cell Biology}

  • Lisa Curtis, PhD
    1. Cellular sources of epithelial repair in AKI
    2. Sex differences in heme oxygenase-1 (HO-1) in the kidney
    3. Pathobiology of AKI in the aging kidney.
  • Christopher A. Klug, Ph.D.

{/slide}

{slide=Hypertension}

  • Edward Inscho, PhD
    1. The control of the renal microcirculation
    2. Autoregulatory impairment in hypertension
    3. Impact of High Dietary salt on afferent arteriole function
  • David Pollock, PhD
    1. Endothelin regulation of sodium homeostasis and salt-sensitive hypertension
    2. Circadian control of blood pressure
    3. Pathogenesis of sickle cell nephropathy
  • Jennifer Pollock, PhD
    1. Endothelin and Nitric Oxide regulation of sodium excretion and salt-sensitive hypertension
    2. Early life stress, vascular disease, and hypertension
    3. Renal tubular function and diabetic nephropathy
  • Paul Sanders, MD
    1. Monoclonal immunoglobulin light chain-related renal diseases, including acute kidney injury, cast nephropathy, monoclonal light chain-related glomerulopathy and amyloidosis, type AL
    2. Hypertensive nephrosclerosis
  • M. Tino Unlap, PhD, CRA
    1. Genetic basis of hypertension 
    2. The role of the Na+/Ca2+ exchanger in hypertension 
    3. The link between oxidative stress and endogenous ouabain in hypertension

{/slide}

{slide=Free Radical Biology}

  • Anupam Agarwal, M.D. 
  • Shannon Bailey, Ph.D.
  • Victor M. Darley-Usmar, Ph.D.
  • Ross Holmes, PhD
    1. Mitochondrial dysfunction in proximal tubular cells
  • Edward Inscho, PhD
    1. The control of the renal microcirculation
    2. Autoregulatory impairment in hypertension
    3. Impact of High Dietary salt on afferent arteriole function
  • Rakesh Patel, PhD
  • Jennifer Pollock, PhD
    1. Endothelin and Nitric Oxide regulation of sodium excretion and salt-sensitive hypertension
    2. Epigenetic and post-translational modifications of Nitric Oxide Synthase
    3. Nitric Oxide Synthase and vascular function
  • M. Tino Unlap, PhD, CRA
    1. Genetic basis of hypertension 
    2. The role of the Na+/Ca2+ exchanger in hypertension 
    3. The link between oxidative stress and endogenous ouabain in hypertension

{/slide}

 

CLINICAL

{slide=CKD, ESRD}

  • Michael Allon, M.D.
  • Emmy Bell, M.D.
  • Orlando Gutierrez, M.D.
  • Eric Judd, MD
    1. Vascular effects of spironolactone in CKD
    2. Vascular amiloride-sensitive sodium channel
  • Bhupesh Panwar, MD
  • Denyse Thornley-Brown, M.D.
  • David G. Warnock, M.D.
    {/slide}

{slide=ICU Nephrology}

  • David Askenazi, MD, MSPH
    1. Epidemiology of Acute Kidney Injury in Neonates
    2. Strategies to prevent Acute Kidney Injury in Neonates
    3. Early peritoneal dialysis to support children after acute cardioulmonary bypass surgery
    4. Negating Injury Nephrotoxins with Just in time Action (NINJA)
    5. Role of Urine biomarkers in improving how and when we diagnose Acute Kidney Injury in Neonates and Children
  • Ashita Tolwani, MD

{/slide}

{slide=Transplantation}

  • Robert Gaston, M.D.
  • Bruce Julian, MD
    1. Genetically Determined Influences of Immunosuppressant Toxicity
    2. Genetically Determined Influences on Allograft Survival
    3. Recurrent IgA Nephropathy
  • Clifton E. Kew, II, M.D.
  • Vineeta Kumar, MD
  • Jayme Locke, MD, MPH
    1. Incompatible kidney transplantation and kidney paired donation.
    2. Kidney transplantation in HIV-positive patients
    3. Disparities in access to and outcomes after kidney transplantation.
  • Shikha Mehta, MD
  • Roslyn Mannon, M.D.
  • Graham Towns, MD
    {/slide}

{slide=Epidemiology and Outcomes}

  • David G. Allison, Ph.D.
  • Xiangqin Cui, Ph.D.
  • Gary Cutter, Ph.D.
  • Orlando Gutierrez, M.D.
  • George Howard, Ph.D.
  • Paul Muntner, PhD
  • Stephen G. Rostand, MD
    1. Pathogenesis and epidemiology of Hypertension and Kidney Disease in Minority Groups
    2. Geographic and Environmental Factors in Hypertension and Kidney Disease

{/slide}

{slide=Inherited kidney disease}

  • Mark Bevensee, PhD
    1. Mechanisms of sodium hyperabsorption and acid-base dysregulation in ARPKD
  • Ross Holmes, PhD
    1. Primary Hyperoxaluria
    2. Nephrolithiasis
  • Michal Mrug, M.D.
  • Dana Rizk, M.D.
  • David G. Warnock, M.D.
    {/slide}

{slide=Sickle Cell Disease}

  • David Pollock, PhD
    1. Endothelin regulation of sodium homeostasis and salt-sensitive hypertension
    2. Circadian control of blood pressure
    3. Pathogenesis of sickle cell nephropathy
  • Denyse Thornley-Brown, M.D.
    {/slide}

{slide=Vascular Access}

  • Michael Allon, M.D.
  • Timmy Lee, MD
    1. Observational Studies in Hemodialysis Vascular Access
    2. Translational Studies Evaluating Vascular Function Prior to Hemodialysis Access Creation
    3. Clinical Trials in Hemodialysis Vascular Access
  • Roman Shingarev, MD
    {/slide}

{slide=Hypertension}

  • Eric Judd, MD
    1. Vascular effects of spironolactone in CKD
    2. Vascular amiloride-sensitive sodium channel
  • Stephen G. Rostand, MD
    1. Pathogenesis and Epidemiology of Hypertension and Kidney Disease in Minority Groups
    2. Geographic and Environmental Factors in Hypertension and Kidney Disease


{/slide}

{slide= Home Hemodialysis and Peritoneal Dialysis}

  • Gaurav Jain, MD
  • Eric Wallace, MD

{/slide}