Seeking healthy participants with no history or diagnosis of mental illness

Seeking healthy participants with no history or diagnosis of mental illness personally or in a first-degree relative — mom, dad, sibling. You must not require medication to treat an existing physical or mental illness/disorder. Individuals abusing alcohol or recreational drugs cannot participate as there will be intensive drug screening — both urine and blood. You must be ages 18-55 and weigh less than 190 lbs. Participants are needed to evaluate the effect of a drug called LY2150023 (Pomaglumetad or "POMA" for short) on a naturally occurring chemical called glutamate in the brain. We will also ask you to receive an intravenous infusion of a drug called ketamine. Study requirements: Screening (visit 1): determine your eligibility for the study, about 2 hours and includes drug testing, a complete medical and neurological check-up; Screening Ketamine MRI (visit 2): drug testing, MRI scan and ketamine infusion to determine study eligibility; Study Day 1 (visit 3): take study medicine in clinic, clinic evaluation, blood draw about 2 hours; Study Day 5 (visit 4): Clinical evaluation, blood draw and checkup about 2 hours; Study 10 (visit 5): Clinical evaluation, blood draw, drug testing, MRI scan and ketamine infusion about 5-6 hours. Three follow up phone calls. As a participant you will receive: $50 for visits 1, 3 and 4; $100 for visit 2; $300 for completion of visit 5 for a total of $600. For further information about the study and your eligibility, please contact Kristen at 996-9813.