The UAB Alzheimer's Disease Center participates in several national collaborative research programs investigating AD and potential new therapies.  These include:

Alzheimer's Clinical Trial Consortium (ACTC). The ACTC provides a clinical trials infrastructure designed to accelerate and expand studies for therapies in Alzheimer's disease and related dementias. ACTC's mission is to provide an optimal infrastructure, utilizing centralized resources and shared expertise, to accelerate the development of effective interventions for Alzheimer’s disease and related disorders. Dr. Geldmacher serves as UAB's representative on the Steering Committee.

Alzheimer's Disease Neuroimaging Initative (ADNI). Since 2005, the longitudinal Alzheimer’s Disease Neuroimaging Initiative (ADNI) has been validating the use of biomarkers including blood tests, tests of cerebrospinal fluid, and MRI/ PET imaging for Alzheimer’s disease (AD) clinical trials and diagnosis. UAB has participated in each phase of this study, including ADNI-1, ADNI-GO, ADNI-2, and now ADNI-3. Dr. Geldmacher is the UAB site PI.

Alzheimer's Disease Genetics Consortium (ADGC). The ADGC is an NIH-funded collaboration between Alzheimer's Disease Centers across the U.S. to identify genetic variants that contribute to AD risk.

ALLFTD: the ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration multisite research consortium. The ALLFTD consortium is an integrated group of academic medical centers partnered with patient support organizations and dedicated to conducting clinical research in sporadic and familial frontotemporal lobar degeneration (FTLD) syndromes. ALLFTD is funded by the National Institutes of Health and Dr. Roberson is the site PI at UAB.

The Frontotemporal Dementia Prevention Initiative (FPI).  The FPI in an international collaboration between the leading FTD research centers, including those involved in the Genetic FTD Initiative (GENFI) in Europe and Canada as well as the Australian Dominantly Inherited Non-Alzheimer Dementias (DINAD) and Research Dementia Latin America (ReDLat) studies.

Alzheimer's Disease Cooperative Study (ADCS). The ADCS was formed in 1991 as a  major initiative for Alzheimer’s disease (AD) clinical studies, addressing treatments for both cognitive and behavioral symptoms, particularly drugs that might not be developed by industry. UAB has participated in many ADCS-sponsored trials, and both Dr. Geldmacher and Dr. Marson have served on ADCS committees.