At any given time, the Department of Anesthesia and Perioperative Medicine has more than 50 ongoing clinical research studies. The Department also hosts several large, multi-center, industry-sponsored trials.
Examples of recent clinical research projects include:
High-Frequency Nerve Block for Post-Amputation Pain: A Pivotal Study (Neuros)
Impact of temperament on the Development of Post-Operative Emergence of Delirium in Children Ages 2 to 8 years
Intraoperative Tourniquet Use and Patients Undergoing Regional Anesthesia
Modifiable Factors that Impact Long-Term Quality of Life and Development of Chronic Pain after Pulmonary Resection
Evaluation of a Method to Increase Adoption of the Optimal Technique for Decreasing Post-Dural Puncture Headaches among Non-Anesthesiologists Performing Diagnostic Lumbar Punctures
Novel Biomarkers of Pre-eclampsia: Aquaporins, Fatty Acids, and S100B
Impact of Preoperative Steroids on Adrenal Insufficiency and Clinical Outcomes after Neonatal Cardiac Surgery with Cardiopulmonary Bypass
Noble Gas Effects on Human Natural Killer Cell Activity and Toxicity
Dose Escalation of Dexamethasone to Increase Duration of Transversus Abdominal Plane Block Following Cesarean Section: A Prospective Randomized Double-Blinded Clinical Study
Sedation and Pain: The Effect of Sedation on Pain Perception
Effect of Sedation on Cognitive Performance in the Elderly
Superficial Cervical Plexus Blockade for Clavicle Fracture Analgesia
Optimal Injection Site for Serratus Anterior Plane Block in Reconstructive Breast Surgery
Effectiveness of Perineural Clonidine as an Adjuvant with Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery
Factors influencing PACU discharge times following spinal anesthesia for cerclage placement and dilation and curettage- a retrospective study
Remote Ischemic Preconditioning Living Donor Renal Transplant Protocol
Red Blood Cell Transfusion May Exacerbate Cerebral Vasospasm Associated with Subarachnoid Hemorrhage
Intraoperative Low-dose Ketamine Infusion for Patients with Obstructive Sleep Apnea: A Prospective, Randomized, Controlled, Double-Blind Study Protocol
Comparison of hemodynamic changes under general anesthesia in patients receiving preoperative block therapy
Intraoperative Hemodynamic Effects and Postoperative Pain Control with a Continuous Epidural Infusion under General Anesthesia
Coagulopathy in Severe Pediatric Trauma with and without Head Injury
Effect of Autonomic Nervous System Activity and Early Coagulation Abnormalities on the Development of Systemic Immunosuppression and Nosocomial Pneumonia in Patients with Vascular or Traumatic Brain Injury
Importance of the Type III Secretion (T3SS) Toxin ExoY in the Severity of P. Aeruginosa Pneumonia in ICU Patients
Coagulopathy and Nosocomial Pneumonia After Severe Trauma
A Clinical Proof-of-Concept Study for the Perioperative Surgical Home
The Role of Exo-induced tau phosphorylation in the development of cognitive dysfunction in ICU patients after nosocomial pneumonia
Utility of Ultrasound in Identification of Midline and Placement of Epidural in Severely Obese Parturients: A Randomized, Prospective Study
Comparing Bupivacaine, Lidocaine, and a Combination of Bupivacaine and Lidocaine for Labor Epidural Activation: A Prospective, Randomized, Double-Blind Study
Comparing Low-dose Bupivacaine with Epidural Volume Extension to Standard Bupivacaine dosing for short obstetric procedures: A prospective, randomized study
Assessment of the Endothelial Glycocalyx of an Ex Vivo Preparation of Human Umbilical Veins after Exposure to a Simulated Colloid and Crystalloid Bolus
A Randomized Controlled Trial of Regional Versus General Anesthesia for Promoting Independence after Hip Fracture (REGAIN trial)
Nitrite Infusion in Islet Cell Transplantation: Test of Clinical Efficacy and Determination of Cytoprotective Mechanisms
Quality Improvement of post-partum neuromuscular complications using retrospective and prospective chart review of a recently instituted clinical protocol
Hospital Naloxone Administration Rates Before and After Implementation of Standardized Patient Controlled Analgesia (PCA) Order Sets and Capnography Monitoring
Oral Morphine Equivalents as a Predictor for Morbidity and/or 30 day Readmission Following Surgery
Incidence of Acute Kidney Injury in Neurologically Injured Patients Receiving Hypertonic Sodium Chloride versus Hypertonic Sodium Acetate Intravenous Solutions
Efficacy of Ketamine Infusion Compared with Traditional Anti-epileptic agents in refractory status epilepticus: a pilot study
Use of Cumulative Summation (CUSUM) Scoring for Defining Competence in Central Venous Line Insertion in Inexperienced Trainees
Volatile anesthetics may upregulate Glioblastoma Multiforme Tumor Promotor
Right Ventricular Dysfunction in Pregnancy-Induced Hypertension: a Pilot Study
The Role of Intravenous Fluid and Vasoactive Agents Resuscitation in the Development of Early Acute Kidney Dysfunction in Two Cohorts of Intensive Care Unit Patients