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More than $82 million NIH grant to propel CCTS forwardThe Center for Clinical and Translational Science based at the University of Alabama at Birmingham has been awarded four grants from the National Center for Advancing Translational Science, part of the National Institutes of Health, totaling $82 million over seven years.
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Type 1 diabetes: B cell-derived natural antibodies suppress autoimmune pathogenesisVaccination of neonatal mice with group A Streptococcus promotes clonal expansion of B cells that produce antibody against GlcNAc. The association of reduced Type 1 diabetes risk after group A Streptococcus infection is dependent on these GlcNAc-specific B cells.
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Flu: Interferon-gamma from T follicular helper cells is required to create lung-resident memory B cellsLung-resident memory B cells produced during influenza are long-living immune cells that migrate to the lungs from draining lymph nodes and lie in wait as early responders that can quickly react to future infections. They are key sentinels against subsequent viral variants.
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