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Initiated in 2009, the annual Methods Symposium is a signature program of the UAB Center for Outcomes and Effectiveness Research and Education. The overarching goal of the Methods Symposium is to provide a general overview and framework for recent developments and novel directions in a health services research (HSR) methodological area. The Symposium is intended for an interdisciplinary and interprofessional HSR audience across the career arc, from students to faculty at all ranks, and includes presentations from national thought leaders in a timely thematic methodological area, culminating with the Meredith Kilgore Endowed Lectureship sponsored by the UAB School of Public Health. The Kilgore Endowed Lectureship was established in 2020 to honor the late Dr. Kilgore’s innumerable contributions to HSR, mentorship, and training at UAB, including roles as Co-Director of the COERE and its AHRQ T32 until his untimely passing in 2019. Previously held in-person, the COERE is pleased to now offer the Symposium in hybrid format.