Professor 
Department Chair
Katharine Reynolds Ireland Chair of Pediatrics
Physician-in-Chief, Children's of Alabama

Division of Pediatric Gastroenterology, Hepatology & Nutrition

Education

Medical School
Mount Sinai School of Medicine
Internship
Johns Hopkins Hospital
Residency
Johns Hopkins Hospital
Fellowship
Cincinnati Children's Hospital Medical Center

Awards

Hinda Kopelman Research Award, Hospital Ste.-Justine
Shwachman Award in Pediatric Gastroenterology, NASPGHAN
Saul Horowitz, Jr. Memorial Award, Mount Sinai

Interests

Research Interests
Identification of mechanisms for the increased susceptibility of infants to toxigenic E. coli diarrhea. His study of the endogenous intestinal peptides guanylin and uroguanylin has resulted in an understanding of their secretory, diuretic, and anti-nociceptive functions. His studies provided, in part, the basis for the development of pharmacologic agonists of the guanylin/uroguanylin receptor, e.g., linaclotide, now used to treat severe constipation and irritable bowel syndrome. His clinical research relates to vaccines for diarrheal diseases including E. coli and cholera diarrhea.

Clinical Interests
Inflammatory bowel disease, celiac disease, diarrheal disease

Education Interests
Training physician scientists; promoting opportunities for primary care physicians to serve the underserved; developing residents, fellows and faculty who look like our patients