Depression

• MicroRNA Mapping in Major Depression (Dwivedi)
• Calcium Sensing Proteins in Depression (Dwivedi)
• Neural correlates of fear conditioning in major depression, a translational study of brain structure and function following early life trauma and stress sensitization within unipolar depression (Grant)
• Obesity, Inflammation, and Depression, which is studying inflammation as a possible link between obesity and depression (Shelton)
• A Phase 2, Multicenter, Randomized, Double-blind,  Placebo-controlled Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Major Depressive Disorders (Shelton)
• A Randomized, Multicenter, Crossover Study to Assess the Preformance Validity and Test-Retest Reliability of a Computer-Administered Cognitive Test Batter in Subjects With Major Depressive Disorder (Shelton)
• A Randomized, Double-blind, Multicenter, Active-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus and Oral Antidepressant in Adult Subjects with treatment-resistant Depression (Shelton)
• A Randomized, Double-blind Multicenter, Active-controlled Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Treatment-resistant Depression (Shelton)
• A Prospective, Longitudinal, Observational Study to Evaluate Potential Predictors of Relalpse in Subjects With Major Depressive Disorder Who Have Responded to Antidepressant Treaatment (Shelton) 
• A double-blind, randomized, placebo controlled study to evaluate the efficacy and safety of intranasal esketamine for the rapid reduction of the symptoms of major depressive disorder, including suicidal ideation, in subjects assessed to be at imminent risk for suicide. (Shelton)

Bipolar Disorder

• A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter, Fixed-dose Clinical Trial Evaluating the Efficacy, Safety and Tolerability of Cariprazine in Patients with Bipolar I Depression

Suicidality

• Plasma Exosomal MicroRNAs as Promising Novel Biomarkers for Suicidality and Treatment Outcome

Stress

• The Role of Epigenetic Regulation of Micro RNAs on Transgenerational Transmission of Early Life Stress Effects (Shelton)
• Early life origins of obesity: the relationships between early life stress and abdominal obesity in depressed patients (Li)
•  Oxidative Stress Mechanisms in Mood Disorders (Shelton)

Circadian Rhythms

• Impact of circadian misalignment induced by off-shift sleep strategies in hospital shift work nurses (Gamble)
• Impact of dysregulation of GSK3 (therapeutic target for lithium and several of psychotropic drugs) on circadian rhythms (Gamble)

For further information, please contact:
UAB Department of Psychiatry - Office of Psychiatric Clinical Research
1720 7th Avenue South
Sparks Building, 10th Floor
Birmingham, AL 35294-0017
Telephone:  (205) 934-2484
Email: psychresearch@uab.edu