Latest DRC News
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New research from the University of Alabama at Birmingham, published in the Journal of Clinical Endocrinology & Metabolism, shows that adults with Type 2 diabetes who follow a low-carbohydrate diet might experience improvements in their beta-cell function, potentially helping them manage their condition more effectively and potentially reduce or eliminate the need for medication.
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While diabetes patients are categorized into two groups, either Type 1 or Type 2, no two patients are the same. The simple categorization often does not portray the disease and its many presentations, especially within different populations. For this reason, diabetes researchers and clinicians have emphasized the importance of growing the understanding of diabetes subtypes.
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The University of Alabama at Birmingham startup TIXiMED, Inc., has obtained clearance from the United States Food and Drug Administration to proceed to clinical trials under an Investigational New Drug for TIX100, its novel oral Type 1 diabetes drug. This represents a major milestone in the development of this new approach to T1D treatment and gives TIXiMED the green light to start human studies with TIX100.
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UAB Comprehensive Diabetes Center (UCDC) Associate Director W. Timothy Garvey, M.D., and collaborators recently published “Cardiometabolic Disease Staging and Major Adverse Cardiovascular Event Prediction in 2 Prospective Cohorts” in the journal JACC: Advances.
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University of Alabama at Birmingham researchers recently presented NIH-funded findings regarding differences in medication acceptance, quality of life, insulin secretion, mortality and other outcomes among four commonly used Type 2 diabetes medications.
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Researchers have discovered the novel mechanism that underlies a previously reported observation that infection by group A Streptococcus bacteria reduces the risk of later developing Type 1 diabetes.
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Usually, a diabetes diagnosis begins with a label: either Type 1 or Type 2 diabetes. Patients with diabetes are typically assigned one of these two labels and then treated accordingly.
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New findings from the University of Alabama at Birmingham indicate that the type of protein in the diet is not as important as the overall amount of weight loss for those with Type 2 diabetes.
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In 2012, University of Alabama at Birmingham researcher Anath Shalev, M.D., reported that a decades-old blood pressure medication called verapamil completely reversed diabetes in animal models. In 2018, the team had translated these findings into a randomized, controlled, clinical trial, demonstrating significantly improved beta cell function for one year in human subjects with recent onset Type 1 diabetes. By last year, in a small follow-up study, Shalev and colleagues had found that adult Type 1 diabetes patients taking oral verapamil required less daily insulin and showed evidence of beneficial immune modulation for as long as two years after first diagnosis.
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The prevalence of Type 2 diabetes in youth is increasing in the United States, primarily among minorities, with Black and Hispanic youth showing the greatest increase. Neither the reason for the increase nor the mechanism underlying the disproportionate risk in minority youth is known.