With leadership from Dr. Marcas Bamman, the National Exercise Clinical Trials Network (NExTNet) has catalogued resources, expertise and equipment inventories across a 57-member consortium of CTSA Hubs and other academic medical centers for testing cardiopulmonary function, neuromuscular function, body composition, and metabolites; resistance training; and endurance or interval training. Among these resources is the Heritage (HEalth, RIsk factors, exercise Training And GEnetics) Family Study, led by Dr. Claude Bouchard of Pennington Biomedical Research Center, representing a major cohort used to document the impact of genetics on cardiovascular, metabolic and hormonal response to exercise. NExTNet has also developed the infrastructure for data sharing for completed exercise studies to support multi-site exercise clinical trials to address these scientific opportunities in a disease-specific or population-specific manner.