Through its support of clinical research expertise, the CCTS extends the capacity of major network initiatives that build on the strengths of the Partner Network and that leverage the opportunities throughout the country in pediatric research. Under the leadership of Drs. Joseph Biggio and Alan Tita, the CCTS’ National Perinatal Research Consortium (NPRC) is working with four other CTSA hubs (Columbia University, and the Universities of North Carolina, Utah, Texas Medical Branch in Galveston) to create a CTSA-supported Perinatal Research Network Consortium for clinical studies not within the purview of the current NICHD-funded Maternal Fetal Medicine Network, which we also support. The NPRC is committed to building a robust research infrastructure providing the highest and most reliable recruitment, retention and data standards to most effectively facilitate perinatal clinical, translational and comparative effectiveness research to improve health outcomes for women, their children, and their families. The group is currently developing the Registry of Rare Events in Obstetrics (RARE) that aims to compile cohorts of women with relatively rare conditions in pregnancy and compare outcomes across centers.