Overview

Molecular Hematopathology is a subdivision within the Division of Genomic Diagnostics & Bioinformatics. The goal of the Molecular Hematopathology Subdivision is to develop and offer moleculartests that facilitaterapid and comprehensive molecular characterization of myeloid and lymphoid neoplasms. 

Training

As part of the molecular genetic pathology rotation, residents and fellows are exposed to specimen triage, interpretation NGS testing of myeloid neoplasms, and interpretation of clonality studies. A portion of the rotation includes a rotation with the Cytogenetics Facility in the Department of Genetics to learn karyotyping, molecular cytogenetics, and FISH. 

Testing

• Targeted Next Generation Sequencing (NGS) Panel for the characterization of myeloid neoplasms.
• Clonality evaluation via B-cell immunoglobulin and T cell receptor gene rearrangement studies.

Projects & Programs

• Development of a rapid targeted NGS assay to capture crucial myeloid mutations such as FLT-3 ITD and fusions such as PML-RARA and others within 24 hours.
• Development of an in-house BCR-ABL1 assay for diagnosis and follow up of chronic myeloid leukemia and B-acute lymphoblastic leukemia with t(9;22).

Section Head: Diana Morlote, M.D.