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Reversal of lung fibrosis in mouse model suggests a novel therapeutic target for pulmonary fibrosis

A Bcl-2 inhibitor that has FDA approval for treatment of several leukemias reversed lung fibrosis in a bleomycin mouse model.

A Bcl-2 inhibitor that has FDA approval for treatment of several leukemias reversed lung fibrosis in a bleomycin mouse model.

Unsheltered homelessness reflects a stack of personal and community risk factors for veterans

The largest such survey ever conducted, led by Stefan Kertesz, M.D., shows that weather, rents and personal factors contribute to unsheltered homelessness.
The largest such survey ever conducted, led by Stefan Kertesz, M.D., shows that weather, rents and personal factors contribute to unsheltered homelessness.

Breast cancer stem cells may use an arteriolar niche to prepare for metastasis

In this arteriolar niche, breast cancer stem cells and arteriolar endothelial cells cross-talk using a well-known signaling pathway. Targeting this pathway may offer therapeutic potential.

In this arteriolar niche, breast cancer stem cells and arteriolar endothelial cells cross-talk using a well-known signaling pathway. Targeting this pathway may offer therapeutic potential.

Experts say childhood trauma leads to an increase in dropout rates, arrests

Research reveals the ripple effects of childhood trauma and school suspensions.
Research reveals the ripple effects of childhood trauma and school suspensions. 

Entrepreneurship professor’s study ranked No. 6 on 2021 list of 100 most influential papers

UAB continues to lead the way in the evolving field of social entrepreneurship: Patrick J. Murphy, Ph.D., has been recognized as one of the field’s top scholars.
UAB continues to lead the way in the evolving field of social entrepreneurship: Patrick J. Murphy, Ph.D., has been recognized as one of the field’s top scholars.

An existing drug may change tumor-associated macrophages back to cancer fighters

The drug Vismodegib, tested in a breast cancer model, is an inhibitor of hedgehog signaling, a form of cell communication manipulated by the tumor microenvironment.
The drug Vismodegib, tested in a breast cancer model, is an inhibitor of hedgehog signaling, a form of cell communication manipulated by the tumor microenvironment.

$1.7M grant supports back pain research

Edwin Aroke, Ph.D., will examine factors, including epigenetics, that play a role in chronic lower back pain in order to improve the quality of life for patients.
Edwin Aroke, Ph.D., will examine factors, including epigenetics, that play a role in chronic lower back pain in order to improve the quality of life for patients.

Why doesn’t weight loss work for me? Smarter studies aim for faster answers

People respond to weight loss strategies in different ways, but typical studies test only one intervention at a time. UAB’s Drew Sayer is testing multiple strategies in a single study.
People respond to weight loss strategies in different ways, but typical studies test only one intervention at a time. UAB’s Drew Sayer is testing multiple strategies in a single study.

Deaths from cardiovascular disease in the stroke belt surpasses rates elsewhere in the nation

UAB researchers found that death due to cardiovascular causes in the Southeastern U.S. is 16 percent higher than in the rest of the country, and an estimated 101,953 additional deaths need to be prevented by 2025 to bridge this gap.
UAB researchers found that death due to cardiovascular causes in the Southeastern U.S. is 16 percent higher than in the rest of the country, and an estimated 101,953 additional deaths need to be prevented by 2025 to bridge this gap.

A microRNA network is the putative mediator of reductive stress in the heart

Understanding how reductive stress is controlled may help personalize treatment of heart failure patients, leading to better outcomes.

Understanding how reductive stress is controlled may help personalize treatment of heart failure patients, leading to better outcomes.

Ovarian cancer: potential therapeutic target identified

The histone methyltransferase DOT1L — the potential target — is overexpressed in ovarian cancer, and high levels of expression correlate with reduced progression-free and overall survival.
The histone methyltransferase DOT1L — the potential target — is overexpressed in ovarian cancer, and high levels of expression correlate with reduced progression-free and overall survival.

Graduate students awarded AMC21 program scholarship to advance biomedical research

Graduate students awarded AMC21 program scholarship to advance biomedical research
Six graduate students in the Academic Medical Center of the 21st Century scholarship program will network with medical professionals, train with top research doctors and receive research funding from the UAB School of Medicine. 

New study uses electrical stimulation to treat depression

UAB is participating in a nationwide study to treat clinically depressed patients with a VNS device — originally created for treatment of seizure disorders.
UAB is participating in a nationwide study to treat clinically depressed patients with a VNS device — originally created for treatment of seizure disorders.

$20M awarded for scientific research to ensure health equity in preventing hypertension

Uncontrolled hypertension, or high blood pressure, is a major health concern in underserved communities.
Uncontrolled hypertension, or high blood pressure, is a major health concern in underserved communities.

First 3-D view of TB granulomas alters paradigm of their shape and formation

MicroCT of infected human lung tissue, along with histology and immunohistochemistry, was used to construct images of TB granulomas, airways and vasculature.

MicroCT of infected human lung tissue, along with histology and immunohistochemistry, was used to construct images of TB granulomas, airways and vasculature.

$1.83 million grant supports behavioral health profession education

Michele Talley, Ph.D., will address ways to improve mental health access and increase the behavioral health workforce in grant-funded study.
Michele Talley, Ph.D., will address ways to improve mental health access and increase the behavioral health workforce in grant-funded study.

Advantages of intranasal vaccination against SARS-CoV-2

Intranasal vaccination is needle-free and elicits immunity at the site of infection, the respiratory tract.
Intranasal vaccination is needle-free and elicits immunity at the site of infection, the respiratory tract.

A small molecule induces readthrough of cystic fibrosis CFTR nonsense mutations

This research suggests that a path to treat currently untreatable cases of cystic fibrosis is clearly achievable.
This research suggests that a path to treat currently untreatable cases of cystic fibrosis is clearly achievable.

Marketing professors present new theoretical model of tacit knowledge transfer

Two Collat School of Business marketing professors support the formation of integrative teams of marketing and sales professionals to facilitate cooperation and meaningful communication, and to mitigate workplace conflict.
Two Collat School of Business marketing professors support the formation of integrative teams of marketing and sales professionals to facilitate cooperation and meaningful communication, and to mitigate workplace conflict.

Melanoma of the eye: preclinical tests show path toward treatment

A small molecule inhibitor has been identified that reduces the growth of uveal melanoma, a rare and deadly cancer of the eye.
A small molecule inhibitor has been identified that reduces the growth of uveal melanoma, a rare and deadly cancer of the eye.

UAB’s Civitan Center names Emerging Scholar Award winners

Part of the mission of the Civitan International Research Center is to foster the next generation of scientists studying brain development.
Part of the mission of the Civitan International Research Center is to foster the next generation of scientists studying brain development.

Business professors develop model of workplace bullying

Business professors develop model of workplace bullying
Researchers developed a workplace bullying model through qualitative research to help identify critical issues and bring awareness to the seriousness of the issue.

The Southern diet — fried foods and sugary drinks — may raise risk of sudden cardiac death

This study is the latest research to investigate the association between cardiovascular disease and diet — which foods have a positive versus negative impact on cardiovascular disease risk.
This study is the latest research to investigate the association between cardiovascular disease and diet — which foods have a positive versus negative impact on cardiovascular disease risk.

Hubbard awarded grant to study heart disease drug’s effects on retina

Hubbard awarded grant to study heart disease drug’s effects on retina
Seth Hubbard, a UAB undergraduate student studying neuroscience, has received a grant to test the efficacy of carvedilol as a treatment for retinal degeneration, while participating in a summer research fellowship with Fight for Sight.

Are hormones from the heart responsible for high nighttime blood pressure?

Investigations by researchers at UAB reveal the existence of a day/night rhythm of heart hormones, and how the disturbance of this rhythm could contribute to a high risk of high blood pressure and poor cardiovascular health in obese individuals.

Investigations by researchers at UAB reveal the existence of a day/night rhythm of heart hormones, and how the disturbance of this rhythm could contribute to a high risk of high blood pressure and poor cardiovascular health in obese individuals.

S. pneumoniae sticks to dying lung cells, worsening secondary infection following flu

This novel virulence trait, which increases severity of S. pneumoniae superinfection, involves pneumococcal surface protein A, now identified as an adhesin.
This novel virulence trait, which increases severity of S. pneumoniae superinfection, involves pneumococcal surface protein A, now identified as an adhesin.

UAB joins oncology clinical trial diversity alliance

The alliance will focus on boosting participation in clinical research within historically underrepresented patient groups. (Photo by: Steve Wood)

The alliance will focus on boosting participation in clinical research within historically underrepresented patient groups. 

Friedman awarded grant for phase 2 of pediatric brain tumor study

Gregory Friedman, M.D., has received a special grant to test various therapy combinations with a form of the herpes virus to improve anti-tumor immune response in children battling brain cancer. (Photo by: Steve Wood)

Gregory Friedman, M.D., has received a special grant to test various therapy combinations with a form of the herpes virus to improve anti-tumor immune response in children battling brain cancer.

Undiagnosed and untreated disease identified in rural South Africa

A comprehensive health-screening program in rural northern KwaZulu-Natal has found a high burden of undiagnosed or poorly controlled non-communicable diseases. (Photo by: Africa Health Research Institute)

A comprehensive health-screening program in rural northern KwaZulu-Natal has found a high burden of undiagnosed or poorly controlled non-communicable diseases.

Will reduction in tau protein protect against Parkinson’s and Lewy body dementias?

New results suggest the answer is no, implying that the role of tau in the pathogenesis of Lewy body dementias is distinct from Alzheimer’s disease.
New results suggest the answer is no, implying that the role of tau in the pathogenesis of Lewy body dementias is distinct from Alzheimer’s disease.
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