Fecal-dominant donor microbes in the recipient patients after fecal microbe transplantation did not correlate with response to anti-PD-1 therapy.
Blood and marrow transplantation strategies have changed significantly over the past four decades; but recipients still experience excess mortality that translates into 8.7 years of life lost, according to researchers in UAB’s Institute for Cancer Outcomes and Survivorship.
The study, led by Barbara Gower, Ph.D., is the first randomized clinical trial of a hypothesis that reducing fat stored around organs, through diet alone, can rescue beta-cell function.
The higher infectivity correlates with mutations that increase viral binding to a cell surface glucosaminoglycan, heparan sulfate.
Pharmacogenomics has become a valuable tool for optimizing treatments and is poised to play an increasing role in clinical care.
This finding upends the long-held paradigm that priming during lung infections takes place only in the draining lymph nodes, and it will be key to developing more efficient vaccinations and therapies for respiratory challenges.
A Bcl-2 inhibitor that has FDA approval for treatment of several leukemias reversed lung fibrosis in a bleomycin mouse model.
In this arteriolar niche, breast cancer stem cells and arteriolar endothelial cells cross-talk using a well-known signaling pathway. Targeting this pathway may offer therapeutic potential.
Understanding how reductive stress is controlled may help personalize treatment of heart failure patients, leading to better outcomes.
MicroCT of infected human lung tissue, along with histology and immunohistochemistry, was used to construct images of TB granulomas, airways and vasculature.