Professor, Graduate Program Director
Volker G094M
(205) 934-6691
Research and Teaching Interests: Cardiovascular pathophysiology, Stem cell biology, Cardiovascular regeneration and therapeutics, Wound healing, Diabetes
Office Hours: By appointment
Education:
- BVSc, Bangalore Veterinary College, UAS, Bangalore, India
- MVSc, Indian Veterinary Research Institute, Bareilly, India
- Ph.D., Indian Veterinary Research Institute, Bareilly, India
Dr. Krishnamurthy earned his BVSc (DVM) degree with honors from Bangalore Veterinary College and completed his Ph.D. in Veterinary Pathology from the Indian Veterinary Research Institute, India. He held faculty appointments at the Feinberg Cardiovascular Research Institute, School of Medicine at Northwestern University, Chicago, and Houston Methodist Research Institute, Texas.
He directs a research program focusing on understanding mechanisms of cardiovascular diseases and developing novel therapeutic strategies to promote cardiac regeneration and repair. Dr. Krishnamurthy’s laboratory is supported through funds from National Institutes of Health and American Heart Association.
-
Research Interests
Dr. Krishnamurthy’s laboratory focuses on several broad research areas:
- studying the molecular mechanisms involved in the progression of cardiovascular diseases (CVD);
- understanding how diabetes influences the pathogenesis of CVD;
- develop novel therapeutic strategies using stem cells, exosomes, and bioengineering tools; and
- diabetic wound healing.
Our laboratory uses molecular biology and modern classical research tools along with relevant surgical mouse models of cardiac diseases, including myocardial infarction (LAD ligation), ischemia reperfusion and hypertrophy (ANG-II and TAC induced), and cutaneous wound healing models. The long-term goal of these studies is to identify new targets that can aid in development of future drugs and new therapies for prevention and treatment of cardiovascular disease complications in diabetes. For further information, please visit the Krishnamurthy lab website.
-
Select Publications
- Suresh Babu S, Thandavarayan RA, Joladarashi D, Jeyabal P, Krishnamurthy S, Bhimaraj A, Youker KA, Krishnamurthy P. MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes. Sci Rep. 2016 Nov 9; 6:36207. doi: 10.1038/srep36207.
- Joladarashi D, Srikanth GVN, Thandavarayan RA, Verma SK, Mackie AR, Khan M, Bhimaraj A, Youker KA, Uribe C, Babu SS, Jeyabal P, Kishore R, Krishnamurthy P. Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34+ Cells Deficient in MicroRNA-377. J Am Coll Cardiol. 2015 Nov 17; 66(20):2214-26. doi: 10.1016/j.jacc.2015.09.009.
- Jeyabal P, Thandavarayan RA, Joladarashi D, Suresh Babu S, Krishnamurthy S, Bhimaraj A, Youker KA, Kishore R, Krishnamurthy P. MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1. Biochem Biophys Res Commun. 2016 Mar 18; 471(4):423-9. doi: 10.1016/j.bbrc.2016.02.065.
- Thandavarayan RA, Srikanth GVN, Joladarashi D, Babu SS, Jeyabal P, Verma SK, Mackie AR, Khan M, Arumugam S, Watanabe K, Kishore R, Krishnamurthy P. Sirtuin-6 deficiency exacerbates diabetes induced impairment of wound healing through NF-kB signaling. Expt. Dermatol. 2015. (http://dx.doi.org/10.1111/exd.12762).
- Joladarashi D, Thandavarayan RA, Babu SS, Krishnamurthy P. Small engine, big power: microRNAs as regulators of cardiac diseases and regeneration. Int J Mol Sci. 2014, 15(9), 15891-15911.
- Babu SS, Joladarashi D, Jeyabal P, Thandavarayan RA, Krishnamurthy P. RNA stabilizing proteins as molecular targets in cardiovascular pathologies. Trends in Cardiovascular Medicine. 2015 Feb 20. pii: S1050-1738(15)00057-2. (DOI: http://dx.doi.org/10.1016/j.tcm.2015.02.006).
- Krishnamurthy P, Thal M, Verma S, Hoxha E, Lambers E, Ramirez V, Qin G, Losordo D, Kishore R. Interleukin-10 Deficiency Impairs Bone Marrow-Derived Endothelial Progenitor Cell Survival and Function in Ischemic Myocardium. Circ Res. 2011, 109:1280-1289.
- Krishnamurthy P, Lambers E, Verma S, Thorne T, Qin G, Losordo DW, Kishore R (2010). Myocardial knock-down of mRNA Stabilizing Protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10 null mice. FASEB J. 2010, 24: 2484-94.
- Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, Kishore R (2009). IL-10 attenuates inflammation mediated left ventricular remodeling after myocardial infarction via activation of STAT-3 and suppression of HuR. Circ Res. 104(2):e9-18.
Visit Dr. Krishnamurthy's NCBI page for a complete list of publications.
-
Academic Distinctions and Professional Societies
- Fellow of American Heart Association (FAHA)
- Outstanding Early Career Investigator Award, AHA
- HMRI President’s Award for Transformational Excellence
- American Heart Association (AHA)
- European Society of Cardiology
- International Society for Interferon and Cytokine Research
- Inflammation Research Association
- Society for Immunology and Immunopathology (SIIP)
- Indian Association of Veterinary Pathologists (IAVP)