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Department of Biomedical Engineering School of Engineering | Heersink School of Medicine

Lei Ye

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Associate Professor email
Volker G094
(205) 996-0887

Research and Teaching Interests: Cardiac tissue engineering, Stem cell biology, Gene and cell therapy, Type 2 diabetes

Office Hours: By appointment

Education:

  • M.D., Shanghai Medical University
  • Ph.D., National University of Singapore, Biomedical Science

Dr. Ye graduated with a medical degree from the Shanghai Medical University, Shanghai, China in 1996. He received his PhD from the Faculty of Medicine, National University of Singapore (NUS) in 2005. After completion of his PhD, Ye continued his research at NUS and was promoted to Senior Research Scientist in July 2010. In Sept 2010, he received an invitation for a position at the University of Minnesota, USA, as was appointed an assistant professor there. He returned to Singapore to join the National Heart Centre Singapore in Nov 2014.

Ye's interest lies in the fields of cardiovascular research. He has published more than 80 papers in peer-reviewed journals, including European Journal of Heart Failure, Diabetologia, Biomaterials, Circulation Research, Circulation, and Cell Stem Cell. His research has received various national and international awards at prestigious scientific congresses, including Singapore Cardiac Society (2006, 2007, 2009), Asian Society for Cardiovascular Surgery (2004-2006), Asian Pacific Congress of Cardiology (2009), European Society of Cardiovascular Surgery (2005), European Society of Cardiology (2007), and American Heart Association (2006 & 2011). He was on the final shortlist for the Vivien Thomas Young Investigator Competition at the Annual Scientific Session of American Heart Association in 2006

 

  • Research Interests

    To develop novel molecular and cellular therapies for the treatment of coronary artery disease, atherosclerosis, and heart failure.

  • Select Publications
    • Liping Su, Xiaocen Kong, Sze Jie Loo, Yu Gao, Bingli Liu, Xiaofei Su, Rinkoo Dalan, Jianhua Ma*, Lei Ye*. Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells. Stem Cell Research and Therapy 2022, 13;13.
    • Tan SH, Loo SZ, Gao Y, Tao ZH, Su LP, Wang CX, Zhang LS, Mu YH, Cui YH, Abdurrachim D, Wang WS, Lalic J, Lim KC, Bu J, Tan RS, Lee TK, Zhang JY, Ye L. Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell–derived cardiomyocytes in a porcine model of acute myocardial infarction. Theranostics 2021; 11(16): 7879-7895.
    • Tao ZH, Loo SJ, Su LP, Tan SH, Tee GZ, Gan SU, Zhang JY, Chen X, Ye L. Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction. Cardiovascular Research 1 June 2021. 117(6): 1578–1591.
    • Ye L, D'Agostino G, Loo SJ, Wang CX, Su LP, Tan SH, Tee GZ, Pua CJ, Pena EM, Cheng RB, Chen WC, Abdurrachim D, Lalic J, Tan RS, Lee TH, Zhang JY, Cook SA, Early regenerative capacity in the porcine heart. Circulation 2018 Dec.;138(24): 2798-2808.
    • Su LP, Kong XC, Lim SY, Loo SJ, Tan SH, Poh KK, Dutton J, Stewart C, Cook S, Su XF, Ma JH, Zhang JY, Ye L. The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Stem Cell Research and Therapy. 2018. 9:313.
    • Ye L, Chang YH, Xiong Q, Zhang PY, Zhang LY, Somasundaram P, Lepley M, Swingen C, Su LP, Wendel JS, Guo J, Jang A, Rosenbush D, Greder L, Dutton JR, Zhang JH, Kamp TJ, Kaufman DS, Ge Y, Zhang JY. Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells. Cell Stem Cell 2014; 15(6): 750-761.
    • Ye L, Zhang PY, Duval S, Liping Su, Xiong Q, Zhang JY. Thymosin β4 increases the potency of transplanted mesenchymal stem cells for myocardial repair. Circulation. 2013; 128: S32-S41.
    • Ye L, Zimmermann WH, Garry DJ, Zhang JY. Patching the Heart: Cardiac Repair from Within and Outside. Circ Res. 2013; 113(7): 922-32.
  • Academic Distinctions and Professional Societies

    Honors and Service

    • American Heart Association Scientific Session Abstract Reviewer. 2012-2014.
    • Member of Reviewer Panel, Open Fund Young Individual Research Grant, NMRC, Singapore. 2019-2022.

    Awards

    • Best Poster Award. 13th Singapore Association for Laboratory Animal Sciences (SALAS) Annual Conference, Singapore. 2019.
    • Singhealth Publish! Award 2018. Singhealth Research. 2019.
    • Travel award of Basic Research Council. American Heart Association Scientific Session. Orlando, USA. 2011.
    • Best Presentation award. The 19th Biennial Congress of Association of Thoracic and Cardiovascular Surgeons of Asia. Seoul, Korea. 2009.
    • Special Achievement Awards. The 17th Asian Pacific Congress of Cardiology. Kyoto, Japan. 2009.
    • Special Achievement Awards. The 17th Asian Pacific Congress of Cardiology. Kyoto, Japan. 2009.
    • Best Paper Award. Chinese University of Hong Kong-Mayo Clinic-Asia Cardiovascular Summit. Hong Kong. 2009.
    • Best Paper Award. International Symposium on Cardiovascular and Neurovascular Medicine (ISCNM) in conjunction with International Heart Failure Symposium. Hong Kong. 2008.
    • Travel Award. Annual Scientific Session of European Society of Cardiology. Vienna, Austria. 2007.
    • Young Investigator Award. The 16th ASEAN Congress of Cardiology, Bali, Indonesia. 2007.
    • Young Investigator Award. The 16th ASEAN Congress of Cardiology, Bali, Indonesia. 2007.
    • Travel Award. The 71st Annual Scientific Meeting of Japanese Circulation Society. Kobe Japan. 2007.
    • Final Shortlist for Vivien Thomas Young Investigator Competition. Annual Scientific Session of American Heart Association of American. Chicago, USA. 2006.
    • C Walton Lillehei Young Investigator's Award. The 14th Annual Meeting of Asian Society for Cardiovascular Surgery. Osaka, Japan. 2006.
    • Rabago Prize Award. The 54th International Congress for European Society of Cardiovascular Surgery. Athens, Greece. 2005.
    • Young Investigator Awards. The Annual Meeting of Singapore Cardiac Society. 2009, 2007, 2006, 2005.
    • Young Investigator Award. The 13th Annual Meeting of Asian Society for Cardiovascular Surgery. Chiang Mai, Thailand. 2005.
    • Young Investigator Award. The 12th Annual Meeting of Asian Society for Cardiovascular Surgery. Istanbul, Turkey. 2004.
    • Young Investigator Award. The 12th international congress on cardiovascular pharmacotherapy. Barcelona, Spain. 2003.
    • Young Investigator Merit Award. The 2nd National Healthcare Group Annual Scientific Congress. Singapore. 2003.