Professor
Shelby 806
(205) 996-6938
Research and Teaching Interests: Biomaterials, Tissue engineering
Office Hours: By appointment
Education:
- B.S., Hanyang University, Seoul, Korea, Textile Engineering
- M.S., Hanyang University, Seoul, Korea, Fiber and Polymer Engineering
- Ph.D., Rice University, Bioengineering
- Peter and Ruth Nicholas Postdoctoral Fellow, The Richard Smalley Institute for Nanoscale Science and Technology and the Department of Chemistry, Rice University
Dr. Ho-Wook Jun is the director of the graduate program in the Department of Biomedical Engineering and the School of Medicine at UAB. Dr. Jun received his Ph.D. in Bioengineering from Rice University in 2004. From 2004-2006, he was the Peter and Ruth Nicholas Postdoctoral Fellow at the Richard Smalley Institute for Nanoscale Science and Technology and in the Department of Chemistry at Rice University. In 2006, he joined the UAB faculty. Dr. Jun is also a co-founder and chief scientific officer of Endomimetics LLC, a company that develops bionanomatrix coatings for cardiovascular stents and other medical implants.
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Recent Courses
- BME 310: Biomaterials
- BME 435/535: Tissue Engineering
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Research Interests
Dr. Jun's research group focuses on nanostructured biomaterials and stem-cell-based tissue regeneration to develop an innovative strategy to treat various diseases. His translational research includes:
- a native endothelium mimicking nanomatrix coating for stents and cardiovascular devices,
- a biomimetic hybrid nanosack to increase the efficacy of pancreatic islet transplantation to treat type I diabetes,
- a biphasic composite nanomatrix gel for treating severe limb injuries, and
- a biomimetic nanomatrix gel to enhance dialysis fistula maturation.
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Select Publications
- Ho-Wook Jun, Lakeshia Taite, and Jennifer West. Nitric Oxide Producing Polyurethanes. Biomacromolecules, 2005, 6, 838-844. Featured as the future of vascular grafts in the New England Journal of Medicine, 2005, 353, 730-731 (clinical implications of basic research).
- Ho-Wook Jun, Virany Yuwono, Sergey Paramonov, and Jeffrey Hartgerink. Enzyme Meidated Degradation of Peptide-Amphiphile Nanofiber Networks. Adv. Mater. 2005, 17, 2612-2617.
- Joel M. Anderson, Adinarayana Andukuri, Dongjin Lim, Ho-Wook Jun. Modulating the gelation properties of self-assembling peptide amphiphiles. ACS Nano, 2009, 3, 3447-3454, PMCID: PMC2787687.
- Meenakshi Kushwaha, Joel M. Anderson, Charles A. Bosworth, Adinarayana Andukuri, William P. Minor, Jack R. Lancaster Jr., Peter G. Anderson, Brigitta C. Brott, Ho-Wook Jun. A nitric oxide releasing, self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devices. Biomaterials, 2010, 31, 1502-1508, PMCID: PMC2813909.
- Dong-Jin Lim, Sergey V. Antipenko, Joel M. Anderson, Kimberly F. Jaimes, Liliana Viera, Bradley R. Stephen, Stacie M.J. Bryant, Brett D. Yancey, Katherine Hughes, Wanxing Cui, John A. Thompson, John A. Corbett, Ho-Wook Jun. Enhanced rat islet function and survival in vitro using a biomimetic self-assembled nanomatrix gel. Tissue Engineering Part A, 2011, 17, 399-406, PMCID: PMC3028993.
- Joel Anderson, Jessica Patterson, Jeremy Vines, Amjad Javed, Shawn Gilbert, Ho-Wook Jun. Biphasic Peptide Amphiphile Nanomatrix Embedded with Hydroxyapatite Nanoparticles for Stimulated Osteoinductive Response. ACS Nano, 2011, 5, 9463-9479, PMCID:PMC3691849. Featured as a top story by the Extracellular Matrix News, November 17, 2011.
- Kiwon Ban, Hun-Jun Park, Sangsung Kim, Adinarayana Andukuri, Kyu-Won Cho, Jung Wook Hwang, Ho Jin Cha, Matthew Kim, Woan-Sang Kim, Ho-Wook Jun, Young-Sup Yoon. Cell therapy with embryonic stem cell-derived cardiomyocytes encapsulated in injectable nanomatrix gel enhances cell engraftment and promotes cardiac repair. ACS Nano, 2014, 8, 10815-10825. PMCID:PMC4212793.
- Grant C Alexander, Jeremy B. Vines, Patrick TJ Hwang, Taeyoun Kim, Jeonga Kim, Brigitta C. Brott, Young-Sup Yoon, Ho-Wook Jun. Novel Multifunctional Nanomatrix Stent Coating Reduces Inflammation in Dynamic Conditions In Vitro and Dilates Arteries Ex Vivo. ACS Applied Materials & Interfaces, 2016, 8, 5178-5187. PMID: 26849167.
- Patrick TJ Hwang, Dong-Jin Lim, Timothy Fee, Grant C Alexander, Ajay Tambralli, Adinarayana Andukuri, Liqun Tian, Wanxing Cui, Joel Berry, Shawn R. Gilbert, Ho-Wook Jun. A bio-inspired hybrid nanosack for graft vascularization at the omentum. Acta Biomaterialia, 2016, 41, 224-234, PMCID: PMC4969099.
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Academic Distinctions and Professional Societies
- Fellow of American Heart Association, 2011
- Coulter Fellow, Wallace H. Coulter Foundation, 2011
- Early Career Award, National Science Foundation, 2010
- Finalist, Alabama Launchpad Governor's Business Plan Competition Endomimetics, LLC (Drs. Brott, Jun, Barr, Schwiebert), 2010
- Dean’s Award for Excellence in Mentorship, 2010
- Innovation Award, American Diabetes Association, 2009
- Featured as one of three selected to the News Conference on “High-Tech for the Heart”, America Heart Association (AHA) Scientific Session 2008
- Early Career Award, Wallace H. Coulter Foundation, 2007-2009
- Society Memberships: Biomedical Engineering Society, Society for Biomaterials, American Heart Association, Tissue Engineering International & Regenerative Medicine Society, American Diabetes Association