Dr. Wang's iCardio-X laboratory is dedicated to the investigation of several focal areas.

1. Developing precise and personalized therapeutic strategies for heart failure by exploring the underlying mechanisms of the disease through various heart failure models.
2. Protein engineering technology is being utilized to decode effective peptides for the treatment of heart failure. By modifying peptides to enhance their stability, bioavailability, and specificity, researchers are able to create more targeted and effective treatments.
3. Translational research is focusing on enhancing cardiac repair through the study of the posttranslational or genetic design of scaffolds in genetically engineered animal models.

1. Wang Y, Ma X. Healthy Coronary Endothelial Cells, Happy Cardiomyocytes. Circulation. 2021 Feb 9;143(6):581-582. doi: 10.1161/CIRCULATIONAHA.120.052535.

2. Xie Y, Meng Z, Gao J, Liu C, Wang J, Guo R, Zhao J, Lopez B, Christopher T, Lee D, Ma X, Wang Y. C1q Complement/Tumor Necrosis Factor-Associated Proteins in Cardiovascular Disease and COVID-19. Proteomes. 2021 Mar 1;9(1):12. doi: 10.3390/proteomes9010012.
3. Meng Z, Liang H, Zhao J, Gao J, Liu C, Ma X, Liu J, Liang B, Jiao X, Cao J, Wang Y. HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis. Life Sci. 2021 Nov 1;284:119935. doi: 10.1016/j.lfs.2021.119935. Epub 2021 Sep 8.
4. Zhao J, Wang Y. Editorial: Functional heart recovery in an adult mammal, the spiny mouse. 2021. Int J Cardiplogy. https://doi.org/10.1016/j.ijcard.2021.08.025
5. Gan L, Liu D, Xie D, Lau WB, Liu J, Christopher T, Lopez B, Liu L, Hu H, Yao P,  He Y,  Gao E, Koch W, Zhao J, Ma X, Cao Y, and Wang Y. Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function. Circulation Research. 2021, https://doi.org/10.1161/CIRCRESAHA.121.320157
6. Yan Z, Wang C, Meng Z, Gan L, Guo R, Liu J, Lau W, Xie D, Zhao J, Lopez B, Christopher T, Naik U, Ma X, Wang Y. C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood-Retinal Barrier Tight Junctions. Cells. 2022 Feb 23;11(5):779. doi: 10.3390/cells11050779.
7. Zhu D, Zhang Z, Zhao J, Liu D, Gan L, Lau WB, Xie D, Meng Z, Yao P, Tsukuda J, Christopher, TA, Lopez BL, Gao E, Koch WJ, Wang Y*, Ma XL. Targeting Adiponectin Receptor 1 Phosphorylation against Ischemic Heart Failure. Circulation Research, 2022, in press. * Co-corresponding author
8. Meng Z, Zhao J, Yao P, Zhang L, Zhang Z, Xie D, Lau WB, Tsukuda J, Christopher TA, Lopez BL, Zhu D, Liu D, Gao E, Ischiropoulos H, Koch WJ, Ma XL, Wang Y. Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and Therapeutic Target against Ischemic Heart Failure in Pre-Diabetic Animals. Circulation. Online. 2023 Feb 20.

• Great-Wall International Cardiology Congress (GW-ICC), Organization Committee

• GW-ICC International Mentored and Exchange Fellowship Program (BIME) Co-founder

• GW-ICC, International Research BCVS/ACRE/CAAC Joint Session, Chair

• American Physiology Society (APS)

• American Heart Association (AHA)

• American Diabetes Association (ADA)

• ACRE

• Society for Redox Biology and Medicine (SfRBM)

• Microcirculation Society

• American Association of University Professors (AAUP)

• The Science Advisory Board (2111 Wilson Blvd., Suite 250, Arlington, VA 22201)

  
  Associate Editor and Editorial Boards:

• Journal of Extracellular Vesicles

• International Journal of Cardiology

• Journal of Molecular Cellular Cardiology

• Cells