Cardiovascular Reparative Medicine and Tissue Engineering (CRMTE) aims to develop future technologies and therapeutic strategies that will serve as treatment for cardiovascular disease.
CRMTE includes basic and translational research involving biomaterial science, tissue engineering, molecular and device therapeutics, and biomolecular reprogramming and delivery for heart reparative purposes. The field deals with understanding the behavior of cells and tissues with or without devices/biomaterials to assist in cardiovascular health and disease using quantitative engineering tools and develop new strategies for engineering, regenerating, and reprogramming human iPS cells, tissues or organs to restore or establish normal function.
Application areas include scaffolds for reparative medicine, stem cell engineering, 3D bioprinting, organoids and organ-on-chip systems, local and systemic
immunomodulation, nano/microparticles for drug or vaccine delivery, and materials-based new diagnostic agents.
CRMTE harnesses the power of materials/devices to stimulate, modulate, and control the body's repair mechanisms to heal stressed tissues or organs functionally. By deeply understanding the mechanisms followed the design of biomaterials/devices/strategies takes cues from the natural tissue or uses organic and inorganic synthesis to improve the function smartly, can provide precise control of biomolecule presentation or delivery, and integrate seamlessly in vivo.
Application Fields
- Nanotechnology/macroparticles/small extracellular vesicles
- Biomaterials and device-based novel diagnostic and therapeutic strategies
- iPS cell engineering and cell reprogramming
- 3D bioprinting
- Organoids and organ-on-dish systems
- Nuclear chromosome structure
- Local and systemic immunomodulation