The Clinical Core catalyzes the translation of bench discoveries to applications that impact human AKI. They achieve this through providing access to curated clinical data from prior clinical studies and new harmonized real world multimodal data from electronic health records (EHR) to support epidemiological studies of AKI and clinical research, including AKI risk-classification, sub-phenotyping, and simulated trials. They also have access to biospecimens from prior studies hosted by the core. Below is a list of detailed services provided by this core:

The Pre-Clinical Core provides the facilities and requisite skills (Animal Models Resource) to generate and study murine models of AKI and provides unique facilities and requisite skills (Renal Physiology Resource) to determine renal physiological changes in AKI. Pre-Clinical s Core services include:

With both the clinical and pre-clinical cores, the Resource Development Core will provide a dynamic resource and platform to develop, test and refine innovations that will accelerate pre-clinical and clinical research. In the pre-clinical area, new analytical approaches in metabolomics as well as functional in vivo imaging will be incubated to probe unique biological characteristics of disease development. In the clinical area, tools for federated machine learning using big EHR data will be developed.