The George M. O'Brien Michigan Kidney Translational Core Center (MKTC)
Summary
The George M. O’Brien Michigan Kidney Translational Core Center (MKTC) was established to assist investigators and clinicians worldwide in kidney disease research. Their core objective is to enable muti-omic multi-scalar data integration. MKTC consists of two Biomedical Cores: The Applied Systems Biology Core (ASBC) and Data Analytics Services Core (DASC). They provide specialized core services as well as user-friendly tools to enable kidney researchers and trainees to apply to their work.
Applied Systems Biology Core (ASBC)
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Description
The Applied Systems Biology Core (ASBC) primary role is to empower national kidney researchers to analyze, integrate and extract pertinent knowledge from multi-omic datasets (genetic, transcriptomic, epigenomic, metabolomic, proteomic data) from model systems and human studies in support of their individual research needs.
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Services
- Clinical and molecular interactions in investigators’ data sets
- Metabolomics driven analysis workflow
- Michigan Manuscript development
- Model systems studies to identify pathways shared cross-species
- Multi-scalar data analysis and integration
- Quantitative morphometric analyses of kidney biopsy samples
- Shared Data Mining Services - Initial study design consultation
- Spatial metabolomics service (sample process and data analysis)
- Structured RNA-DNA sequence data integration
- Transcript driven data-mining workflow - Single cell RNA Sequencing analysis pipeline
- Transcript driven data-mining workflow - Streamlined self-organizing map (SOM) to identify functional subgroups
- Transcript driven data-mining workflow - Weighted Correlation Network Analysis (WGCNA) to identify co-expressed molecular elements within datasets
Data Analytic Services Core (DASC)
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Description
The Data Analytic Services Core (DASC) provides access to unique sets of data through distinct data analysis platforms. The database is updated quarterly to provide investigators with quick and easy access to all the data being generated as part of the Center and their web portals include sophisticated and user-friendly analytic tools that allow for mining of these datasets.
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Services
- CELLxGENE and Vitessce - access/training/support
- Develop generalized workflow for integrative web-based analysis
- Investigating biomarker association (gene, protein, metabolite level) in clinical existing cohorts through TranSMART instance
- Michigan Manuscript development
- Nephroseq - access/training/support
- TranSMART - access/training/support
Contact Information
If you would like more information regarding services provided by MKTC, please contact:
Wenjun Ju
Website