The overall goal of the Physiology Core is to elucidate, at a molecular and cellular level, the function and regulation of key proteins involved in kidney health and disease. The Core provides in vitro and in vivo technologies to explore the function and regulation of membrane transporters, channels, and other resident proteins using single molecule approaches, model organisms, and native epithelia. Services provided are listed below:

The overall goal of the Model Systems Core is to provide a diverse array of innovative model systems ranging from yeast, tocultured kidney cells and organoids, to whole animal rodent models to understand and explore kidney development, function, and systemic physiology in normal and disease states. Core directors will facilitate integration between these model systems, enabling investigators to test hypotheses at multiple resolutions from molecules to cells to tubules to whole animals. Services provided are listed below:

The KIDNIT Resource Development Core provides a national resource for investigators who require detailed and quantitative morphological analysis of kidney-associated cells and tissues, particularly those that are epithelial in nature, as well as whole organs. Services include: